Evidence map›Paper›PMID 27792877›Full record

ArticleBioconjugate chemistry2017

Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing.

Yong Il Park, Eunha Kim, Chen-Han Huang, Ki Soo Park, Cesar M Castro, Hakho Lee, Ralph Weissleder

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yong Il Park
Eunha Kim
Chen-Han Huang
Ki Soo Park
Cesar M Castro
Hakho Lee
Ralph WeisslederDepartment of Systems Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

Funding

TREATMENT OF CANCER WITH siRNA DELVIERED BY NANOPARTICLESU54CA119349 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELCHER, ANGELA M. · 2005 to 2009
$20.5M
Training Grant in Molecular Imaging Research (MGH/HMS)T32CA079443 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2025
$10.1M
Magnetic nanoswitches for sensing biomoleculesR01EB004626 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2004 to 2012
$3.2M
Novel Clickdyes for Biomedical SensingR01EB010011 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2010 to 2017
$3.1M
MAGNETIC NANOSENSORS FOR BIOMEDICAL ANALYSES OF MICROVESICLESR01HL113156 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO · 2012 to 2016
$2.1M
Multiplexed analysis of exosomes in cancer nano therapyR01CA204019 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2016 to 2020
$1.9M
Multiplexed exosome analyses with DNA barcodingR21CA205322 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO · 2016 to 2017
$440k
NCI NIH HHS R01 CA204019NCI NIH HHS R21 CA205322NCI NIH HHS T32 CA079443NCI NIH HHS U54 CA119349NHLBI NIH HHS HHSN268201000044CNHLBI NIH HHS R01 HL113156NIBIB NIH HHS R01 EB004626NIBIB NIH HHS R01 EB010011
6 · The paper itself

Abstract

The use of inorganic nanoparticles (NPs) for biosensing requires that they exhibit high colloidal stability under various physiological conditions. Here, we report on a general approach to render hydrophobic NPs into hydrophilic ones that are ready for bioconjugation. The method uses peglyated polymers conjugated with multiple dopamines, which results in multidentate coordination. As proof-of-concept, we applied the coating to stabilize ferrite and lanthanide NPs synthesized by thermal decomposition. Both polymer-coated NPs showed excellent water solubility and were stable at high salt concentrations under physiological conditions. We used these NPs as molecular-sensing agents to detect exosomes and bacterial nucleic acids.

Indexed as

Biosensing TechniquesHydrophobic and Hydrophilic InteractionsInorganic ChemicalsNanoparticlesInorganic Chemicals

Identifiers

PMID27792877
PMCPMC5474933

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.