ArticleJournal of biomedical optics2016
Hyperspectral imaging fluorescence excitation scanning for colon cancer detection.
Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Medical hyperspectral imaging: an updated review of technology advancements and biomedical applications.Journal of biomedical optics · 2026Pooled it
- Combined excitation scan-based hyperspectral imaging and digital deconvolution for the assessment of the kinetic and spatial distributions of cAMP signals.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Illuminating native fluorescence signatures for cancer detection.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Optimization of Transfer Learning of Foundation Models for Hyperspectral Histologic Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Multichrome encoding-based multiplexed, spatially resolved imaging reveals single-cell RNA epigenetic modifications heterogeneity.Nature communications · 2025Article
- Design of Multiplexed, Live Cell Imaging Experiments Using Excitation Scan-Based Hyperspectral Imaging Microscopy.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- A naturally brighter approach to colorectal cancer detection.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Hyperspectral imaging facilitating resect-and-discard strategy through artificial intelligence-assisted diagnosis of colorectal polyps: A pilot study.Cancer medicine · 2024Article
- Fluorescence excitation-scanning hyperspectral imaging with scalable 2D-3D deep learning framework for colorectal cancer detection.Scientific reports · 2024Article
- Handheld hyperspectral imaging as a tool for the post-mortem interval estimation of human skeletal remains.Heliyon · 2024Article
- Colon Disease Diagnosis with Convolutional Neural Network and Grasshopper Optimization Algorithm.Diagnostics (Basel, Switzerland) · 2023Article
- In vivo evaluation of a hyperspectral imaging system for minimally invasive surgery (HSI-MIS).Surgical endoscopy · 2023Article
- Multifaceted mirror array illuminator for fluorescence excitation-scanning spectral imaging microscopy.Journal of biomedical optics · 2023Article
- Spectral organ fingerprints for machine learning-based intraoperative tissue classification with hyperspectral imaging in a porcine model.Scientific reports · 2022Article
- Enhancing scanning electrochemical microscopy's potential to probe dynamic co-culture systemsThe Analyst · 2022Article
- First-in-human pilot study of snapshot multispectral endoscopy for early detection of Barrett's-related neoplasia.Journal of biomedical optics · 2021Article
- Advances in optical gastrointestinal endoscopy: a technical review.Molecular oncology · 2021Review
- Autofluorescence-spectral imaging as an innovative method for rapid, non-destructive and reliable assessing of soybean seed quality.Scientific reports · 2021Article
- Article
- Excitation-scanning hyperspectral video endoscopy: enhancing the light at the end of the tunnel.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Optical spectroscopy and hyperspectral imaging have shown the potential to discriminate between cancerous and noncancerous tissue with high sensitivity and specificity. However, to date, these techniques have not been effectively translated to real-time endoscope platforms. Hyperspectral imaging of the fluorescence excitation spectrum represents new technology that may be well suited for endoscopic implementation. However, the feasibility of detecting differences between normal and cancerous mucosa using fluorescence excitation-scanning hyperspectral imaging has not been evaluated. The goal of this study was to evaluate the initial feasibility of using fluorescence excitation-scanning hyperspectral imaging for measuring changes in fluorescence excitation spectrum concurrent with colonic adenocarcinoma using a small pre-pilot-scale sample size. Ex vivo analysis was performed using resected pairs of colorectal adenocarcinoma and normal mucosa. Adenocarcinoma was confirmed by histologic evaluation of hematoxylin and eosin (H&E) permanent sections. Specimens were imaged using a custom hyperspectral imaging fluorescence excitation-scanning microscope system. Results demonstrated consistent spectral differences between normal and cancerous tissues over the fluorescence excitation range of 390 to 450 nm that could be the basis for wavelength-dependent detection of colorectal cancers. Hence, excitation-scanning hyperspectral imaging may offer an alternative approach for discriminating adenocarcinoma from surrounding normal colonic mucosa, but further studies will be required to evaluate the accuracy of this approach using a larger patient cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.