ArticlePloS one2016
Heritable DNA Methylation in CD4+ Cells among Complex Families Displays Genetic and Non-Genetic Effects.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A.The American journal of clinical nutrition · 2020Pooled it
- Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor α.JAMA cardiology · 2018Pooled it
- RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood.Genome biology · 2025Article
- Article
- Frailty and Biological Age.Annals of geriatric medicine and research · 2021Article
- Genetic impacts on DNA methylation: research findings and future perspectives.Genome biology · 2021Review
- IMAGE: high-powered detection of genetic effects on DNA methylation using integrated methylation QTL mapping and allele-specific analysis.Genome biology · 2019Article
- Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease.Nature communications · 2019Article
- Characterization of the contribution of shared environmental and genetic factors to metabolic syndrome methylation heritability and familial correlations.BMC genetics · 2018Article
- Epigenetics, heritability and longitudinal analysis.BMC genetics · 2018Article
- Causal modeling in a multi-omic setting: insights from GAW20.BMC genetics · 2018Article
- Transgenerational and intergenerational epigenetic inheritance in allergic diseases.The Journal of allergy and clinical immunology · 2018Review
- Data for GAW20: genome-wide DNA sequence variation and epigenome-wide DNA methylation before and after fenofibrate treatment in a family study of metabolic phenotypes.BMC proceedings · 2018Article
- Breast cancer family history and allele-specific DNA methylation in the legacy girls study.Epigenetics · 2018Article
- Modeling methylation data as an additional genetic variance component.BMC proceedings · 2018Article
- Article
- Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era.Genome biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
DNA methylation at CpG sites is both heritable and influenced by environment, but the relative contributions of each to DNA methylation levels are unclear. We conducted a heritability analysis of CpG methylation in human CD4+ cells across 975 individuals from 163 families in the Genetics of Lipid-lowering Drugs and Diet Network (GOLDN). Based on a broad-sense heritability (H2) value threshold of 0.4, we identified 20,575 highly heritable CpGs among the 174,445 most variable autosomal CpGs (SD > 0.02). Tests for associations of heritable CpGs with genotype at 2,145,360 SNPs using 717 of 975 individuals showed that ~74% were cis-meQTLs (< 1 Mb away from the CpG), 6% of CpGs exhibited trans-meQTL associations (>1 Mb away from the CpG or located on a different chromosome), and 20% of CpGs showed no strong significant associations with genotype (based on a p-value threshold of 1e-7). Genes proximal to the genotype independent heritable CpGs were enriched for functional terms related to regulation of T cell activation. These CpGs were also among those that distinguished T cells from other blood cell lineages. Compared to genes proximal to meQTL-associated heritable CpGs, genotype independent heritable CpGs were moderately enriched in the same genomic regions that escape erasure during primordial germ cell development and could carry potential for generational transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.