Evidence map›Paper›PMID 27792648›Full record

ArticleJournal of the American Heart Association2016

Sulfur Dioxide Protects Against Collagen Accumulation in Pulmonary Artery in Association With Downregulation of the Transforming Growth Factor β1/Smad Pathway in Pulmonary Hypertensive Rats.

Wen Yu, Die Liu, Chen Liang, Todd Ochs, Stella Chen, Selena Chen, Shuxu Du, Chaoshu Tang, Yaqian Huang, Junbao Du and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Effects of gas signaling molecule SOThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Endothelial Cell-Derived SOOxidative medicine and cellular longevity · 2021
    Article
  8. Article
  9. Sulfur Dioxide Activates ClFrontiers in pharmacology · 2019
    Article
  10. SOFrontiers in chemistry · 2018
    Review
  11. Article
  12. Article
  13. Sulfur dioxide improves endothelial dysfunction by downregulating the angiotensin II/ATJournal of the renin-angiotensin-aldosterone system : JRAAS
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Wen YuDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Die LiuDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Chen LiangDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Todd OchsFeinberg School of Medicine, Northwestern University, Chicago, IL.
Stella ChenDepartment of Biochemistry and Cellular Biology, University of California, San Diego, La Jolla, CA.
Selena ChenDepartment of Biochemistry and Cellular Biology, University of California, San Diego, La Jolla, CA.
Shuxu DuDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Chaoshu TangDepartment of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing, China.
Yaqian HuangDepartment of Pediatrics, Peking University First Hospital, Beijing, China yaqianhuang@126.com junbaodu1@126.com jinhongfang51@126.com.
Junbao DuDepartment of Pediatrics, Peking University First Hospital, Beijing, China Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing, China yaqianhuang@126.com junbaodu1@126.com jinhongfang51@126.com.
Hongfang JinDepartment of Pediatrics, Peking University First Hospital, Beijing, China yaqianhuang@126.com junbaodu1@126.com jinhongfang51@126.com.
Peking University First Hospital · CNPeking University · CNUniversity of California, San Diego · USMinistry of Education of the People's Republic of China · CNNorthwestern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to explore the role of endogenous sulfur dioxide (SO METHODS AND

resultsA rat model of monocrotaline-induced pulmonary vascular collagen remodeling was developed and administered with l-aspartate-β-hydroxamate or SO

conclusionsEndogenous SO

Indexed as

AnimalsAspartate AminotransferasesCells, CulturedCollagenDisease Models, AnimalDown-RegulationFibroblastsHypertension, PulmonaryMaleMonocrotalinePulmonary ArteryRatsRats, WistarSignal TransductionSmad ProteinsSulfur DioxideAspartate AminotransferasesCollagenMonocrotalineSmad ProteinsSulfur DioxideTgfb1 protein, ratTransforming Growth Factor beta1collagen depositionpulmonary arterySmad2/3 signalsulfur dioxidetransforming growth factor β

Identifiers

PMID27792648
PMCPMC5121494
OpenAlexW2533884360

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.