Evidence map›Paper›PMID 27791991›Full record

SynthesisOncotarget2017

Impact of surgical margin status on the outcome of bladder cancer treated by radical cystectomy: a meta-analysis.

Xuwei Hong, Tieqiu Li, Fengsheng Ling, Dashan Yang, Lina Hou, Fei Li, Wanlong Tan

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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  17. The current status of robot-assisted cystectomy.Indian journal of urology : IJU : journal of the Urological Society of India
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xuwei HongDepartment of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Tieqiu LiDepartment of Urology, The People's Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University, Changsha, P. R. China.
Fengsheng LingDepartment of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Dashan YangDepartment of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Lina HouDepartment of Healthy Management, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Fei LiDepartment of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Wanlong TanDepartment of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Nanfang Hospital · CNSouthern Medical University · CNHunan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data regarding the association between surgical margin status and the outcome of bladder cancer treated by radical cystectomy (RC) are conflicting. Therefore, the present meta-analysis was performed to assess the associations between the outcomes of bladder cancer, in terms of recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS), and the presence of positive surgical margins versus negative surgical margins following treatment with RC. Research articles published prior to April 2016 were identified from Pubmed, Embase and the Cochrane Library databases. A total of 36 articles were included, with a sample size of 38,384 bladder cancer patients. Of these, 4,354 patients were reported to have positive surgical margins. Significant associations were detected between positive surgical margins following RC and unfavorable RFS [summary relative risk estimate (SRRE), 1.63; 95% confidence interval (CI), 1.46-1.83; P = 0.105], CSS (SRRE, 1.82; 95% CI, 1.63-2.04; P = 0.001) and OS (SRRE, 1.68; 95% CI, 1.58-1.80; P = 0.805), by fixed or random effects models. The findings were consistent independently of age, sample size, publication year, follow-up duration, study type and geographical region. In summary, the present findings demonstrate that the presence of positive surgical margins is associated with poor survival outcomes in bladder cancer following RC, indicating that avoidance of positive surgical margins during surgery is helpful to improve the prognosis of patients with bladder cancer.

Indexed as

Margins of ExcisionCystectomyDisease-Free SurvivalHumansLymphatic MetastasisNeoplasm Recurrence, LocalNeoplasm StagingPrognosisTreatment OutcomeUrinary Bladder Neoplasmsbladder cancermeta-analysisoutcomeradical cystectomysurgical margin status

Identifiers

PMID27791991
PMCPMC5370038
OpenAlexW2532105859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.