ArticleVirulence2017
Differing mechanisms of surviving phagosomal stress among group B Streptococcus strains of varying genotypes.
Article in Virulence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 39 citations in OpenAlex.
- CorAVeterinary research · 2026Article
- Genomic adaptation in group BmBio · 2026Article
- Genomic adaptation in group BbioRxiv : the preprint server for biology · 2025Article
- Impact of antibiotics on membrane vesicle production in Group BMicrobiology spectrum · 2025Article
- Group B Streptococcal Membrane Vesicles Induce Proinflammatory Cytokine Production and Are Sensed in an NLRP3 Inflammasome-Dependent Mechanism in a Human Macrophage-like Cell Line.ACS infectious diseases · 2025Article
- An opportunistic pathogen under stress: how Group B Streptococcus responds to cytotoxic reactive species and conditions of metal ion imbalance to survive.FEMS microbiology reviews · 2024Review
- Specific interaction between Group BInfection and immunity · 2024Article
- The PI3K-Akt pathway is a multifaceted regulator of the macrophage response to diverse group BFrontiers in cellular and infection microbiology · 2023Article
- Dysregulated monocyte-derived macrophage response to Group BFrontiers in immunology · 2023Article
- Macrophage polarization duringFrontiers in microbiology · 2023Article
- The Role of Regulator Catabolite Control Protein A (CcpA) in Streptococcus agalactiae Physiology and Stress Response.Microbiology spectrum · 2022Article
- Article
- Differential Interaction between Invasive Thai Group BMicroorganisms · 2022Article
- Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy.Nature communications · 2022Article
- Nitric Oxide InducedMicroorganisms · 2022Article
- Copper Intoxication in Group B Streptococcus Triggers Transcriptional Activation of theJournal of bacteriology · 2021Article
- Distinct Group BInfection and immunity · 2021Article
- Production and Composition of Group B Streptococcal Membrane Vesicles Vary Across Diverse Lineages.Frontiers in microbiology · 2021Article
- The impact of Lactobacillus on group B streptococcal interactions with cells of the extraplacental membranes.Microbial pathogenesis · 2020Article
- Modulation of Death and Inflammatory Signaling in Decidual Stromal Cells following Exposure to Group BInfection and immunity · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Group B Streptococcus (GBS), a leading cause of neonatal sepsis and meningitis, asymptomatically colonizes up to 30% of women and can persistently colonize even after antibiotic treatment. Previous studies have shown that GBS resides inside macrophages, but the mechanism by which it survives remains unknown. Here, we examined the ability of 4 GBS strains to survive inside macrophages and then focused on 2 strains belonging to sequence type (ST)-17 and ST-12, to examine persistence in the presence of antibiotics. A multiple stress medium was also developed using several stressors found in the phagosome to assess the ability of 30 GBS strains to withstand phagosomal stress. The ST-17 strain was more readily phagocytosed and survived intracellularly longer than the ST-12 strain, but the ST-12 strain was tolerant to ampicillin unlike the ST-17 strain. Exposure to sub-inhibitory concentrations of ampicillin and erythromycin increased the level of phagocytosis of the ST-17 strain, but had no effect on the ST-12 strain. In addition, blocking acidification of the phagosome decreased the survival of the ST-17 strain indicating a pH-dependent survival mechanism for the ST-17 strain. Congruent with the macrophage experiments, the ST-17 strain had a higher survival rate in the multiple stress medium than the ST-12 strain, and overall, serotype III isolates survived significantly better than other serotypes. These results indicate that diverse GBS strains may use differing mechanisms to persist and that serotype III strains are better able to survive specific stressors inside the phagosome relative to other serotypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.