ReviewVirulence2017
Mining the oral mycobiome: Methods, components, and meaning.
Review in Virulence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed.
- [Age-Related Changes in the Oral Microbiota].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Oral Mycobiome: Composition, Functionality and Clinical Implication.Journal of fungi (Basel, Switzerland) · 2026Review
- A myco-management problem: improving utilization of fungal and mycobacterial smear and culture.Journal of clinical microbiology · 2026Article
- In Vitro Evaluation of the Antifungal Activity and Cytotoxicity ofPathogens (Basel, Switzerland) · 2026Article
- Comparison of oral mycobiota diversity among healthy removable acrylic denture wearers and nondenture wearers: An exploratory pilot study.Journal of Indian Prosthodontic Society · 2026Article
- The pediatric oral mycobiome: a comprehensive review of its role in health and disease.Frontiers in cellular and infection microbiology · 2026Review
- Oral fungal microbiome in gout: composition, cross-kingdom interactions, and effects of intervention.Journal of oral microbiology · 2026Article
- Review
- Salivary mycobial profiles of oral cancer patients - a cohort study.Journal of oral microbiology · 2026Article
- Correlation Between Fungal and Bacterial Populations in Periodontitis Through Targeted Sequencing: A Pilot Study.Journal of clinical medicine · 2025Article
- Inter-kingdom interactions and environmental influences on the oral microbiome in severe early childhood caries.Microbiology spectrum · 2025Article
- Investigation of the optimal condition for the growth and biofilm development ofIranian journal of microbiology · 2025Article
- Oral fungal dysbiosis and systemic immune dysfunction in Chinese patients with schizophrenia.Translational psychiatry · 2024Article
- EnsembleSeq: a workflow towards real-time, rapid, and simultaneous multi-kingdom-amplicon sequencing for holistic and resource-effective microbiome research at scale.Microbiology spectrum · 2024Article
- Oral Mycobiota: A Narrative Review.Dentistry journal · 2024Review
- The oral microbiome: diversity, biogeography and human health.Nature reviews. Microbiology · 2024Review
- Optimization of a DNA extraction protocol for improving bacterial and fungal classification based on Nanopore sequencing.Access microbiology · 2024Article
- Investigating Metabolic and Molecular Ecological Evolution of Opportunistic Pulmonary Fungal Coinfections: Protocol for a Laboratory-Based Cross-Sectional Study.JMIR research protocols · 2023Article
- Nutritional Provision of Iron Complexes by the Major Allergen Alt a 1 to Human Immune Cells Decreases Its Presentation.International journal of molecular sciences · 2023Article
- The Role of the Mycobiome in Women's Health.Journal of fungi (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Research on oral fungi has centered on Candida. However, recent internal transcribed spacer (ITS)-based studies revealed a vast number of fungal taxa as potential oral residents. We review DNA-based studies of the oral mycobiome and contrast them with cultivation-based surveys, showing that most genera encountered by cultivation have also been detected molecularly. Some taxa such as Malassezia, however, appear in high prevalence and abundance in molecular studies but have not been cultivated. Important technical and bioinformatic challenges to ITS-based oral mycobiome studies are discussed. These include optimization of sample lysis, variability in length of ITS amplicons, high intra-species ITS sequence variability, high inter-species variability in ITS copy number and challenges in nomenclature and maintenance of curated reference databases. Molecular surveys are powerful first steps to characterize the oral mycobiome but further research is needed to unravel which fungi detected by DNA are true oral residents and what role they play in oral homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.