Evidence map›Paper›PMID 27791287›Full record

ArticleMagnetic resonance in medicine2017

Diffusion tensor spectroscopic imaging of the human brain in children and adults.

Kevin Fotso, Stephen R Dager, Alec Landow, Elena Ackley, Orrin Myers, Mindy Dixon, Dennis Shaw, Neva M Corrigan, Stefan Posse

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. High-resolution, 3D multi-TEMagnetic resonance in medicine · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kevin FotsoDepartment of Neurology, University of New Mexico, Albuquerque, New Mexico, USA.
Stephen R DagerDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Alec LandowDepartment of Neurology, University of New Mexico, Albuquerque, New Mexico, USA.
Elena AckleyDepartment of Neurology, University of New Mexico, Albuquerque, New Mexico, USA.
Orrin MyersDepartment of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
Mindy DixonSeattle Children's Hospital, Seattle, Washington, USA.
Dennis ShawDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Neva M CorriganDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Stefan PosseDepartment of Neurology, University of New Mexico, Albuquerque, New Mexico, USA.
University of New Mexico · USSeattle Children's Hospital · USUniversity of Washington · US

Funding

Cellular and molecular mechanisms governing cortical surface area overgrowth in iPSC-derived neural cells from longitudinally characterized individuals with autismR01HD055741 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Piven · 2007 to 2026
$52.6M
UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
University of New Mexico Clinical and Translational Science CenterUL1TR000041 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LARSON, RICHARD S · 2012 to 2014
$9.8M
Diffusion tensor MR spectroscopic imaging in human brainR21EB011606 · NIBIB · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI POSSE, STEFAN · 2011 to 2012
$389k
NCATS NIH HHS UL1 TR000041NCATS NIH HHS UL1 TR001449NIBIB NIH HHS R21 EB011606NICHD NIH HHS R01 HD055741
6 · The paper itself

Abstract

purposeWe developed diffusion tensor spectroscopic imaging (DTSI), based on proton-echo-planar-spectroscopic imaging (PEPSI), and evaluated the feasibility of mapping brain metabolite diffusion in adults and children.

methodsPRESS prelocalized DTSI at 3 Tesla (T) was performed using navigator-based correction of movement-related phase errors and cardiac gating with compensation for repetition time (TR) related variability in T

resultsAfter correction for PEG, metabolite slice-averaged MD estimated at 20% PEG were lower (P < 0.042) for adults (0.17/0.20/0.18 × 10

conclusionThis high-speed DTSI approach with PEG regression allows for estimation of metabolite MD and FA with improved tolerance to movement. Our preliminary data suggesting age-related changes support DTSI as a sensitive technique for investigating intracellular markers of biological processes. Magn Reson Med 78:1246-1256, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Indexed as

AdolescentAdultBrainChild, PreschoolDiffusion Tensor ImagingFemaleHumansImage Processing, Computer-AssistedInfantMagnetic Resonance ImagingMaleMiddle AgedPhantoms, ImagingYoung Adultage dependencediffusion tensorhuman brainmagnetic resonance spectroscopic imagingmagnetic resonance spectroscopy

Identifiers

PMID27791287
PMCPMC5409876
OpenAlexW2540163866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.