Evidence map›Paper›PMID 27791149›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

Cardiac arrhythmia in a mouse model of sodium channel

Chad R Frasier, Jacy L Wagnon, Yangyang Oliver Bao, Luke G McVeigh, Luis F Lopez-Santiago, Miriam H Meisler, Lori L Isom

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 77 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chad R FrasierDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109.
Jacy L WagnonDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109.
Yangyang Oliver BaoDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109.
Luke G McVeighDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109.
Luis F Lopez-SantiagoDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109.
Miriam H MeislerDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109.
Lori L IsomDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109; lisom@umich.edu.ORCID http://orcid.org/0000-0002-9479-6729
University of Michigan · US

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
TRAINING IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007853 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David J. Pinsky · 1996 to 2026
$11.6M
The neuronal sodium channel gene SCN8AR01NS034509 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MIRIAM H MEISLER · 1996 to 2026
$9.5M
SUDEP Research Alliance: iPSC and Mouse Neurocardiac Models, Application 6 of 7U01NS090364 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L., PARENT, JACK M · 2014 to 2018
$3.3M
Role of Sodium Channel SCN1B in Inherited EpilepsyR01NS076752 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 2011 to 2014
$1.6M
NCATS NIH HHS UL1 TR000433NHLBI NIH HHS T32 HL007853NINDS NIH HHS R01 NS034509NINDS NIH HHS R01 NS076752NINDS NIH HHS U01 NS090364
6 · The paper itself

Abstract

Patients with early infantile epileptic encephalopathy (EIEE) are at increased risk for sudden unexpected death in epilepsy (SUDEP). De novo mutations of the sodium channel gene

Indexed as

arrhythmiachannelopathyepilepsymutationsodium channel

Identifiers

PMID27791149
PMCPMC5111690
OpenAlexW2546338548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.