ArticleProceedings of the National Academy of Sciences of the United States of America2016
Situating the default-mode network along a principal gradient of macroscale cortical organization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,325 papers, 2 of them syntheses that pooled it.
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1,325 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- Distinct electroencephalography alpha-band rhythms map macroscale brain gradients.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
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- Resolving the Abstract-Concrete Paradox in the Angular Gyrus: A Multimethod Investigation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Retinotopic coding organizes the interaction between internally and externally oriented brain networks.eLife · 2026Article
- Functional neurological disorder, suggestion and virtual reality: neuroanatomical and computational perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Precision fMRI reveals densely interdigitated network patches with conserved motifs in the lateral prefrontal cortex.Neuron · 2026Article
1,265 more citing papers are in PubMed but not listed here.
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Abstract
Understanding how the structure of cognition arises from the topographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, but an overarching framework for the association between structure and function is still lacking. Here, we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored by, at one end, regions serving primary sensory/motor functions and at the other end, transmodal regions that, in humans, are known as the default-mode network (DMN). These DMN regions exhibit the greatest geodesic distance along the cortical surface-and are precisely equidistant-from primary sensory/motor morphological landmarks. The principal gradient also provides an organizing spatial framework for multiple large-scale networks and characterizes a spectrum from unimodal to heteromodal activity in a functional metaanalysis. Together, these observations provide a characterization of the topographical organization of cortex and indicate that the role of the DMN in cognition might arise from its position at one extreme of a hierarchy, allowing it to process transmodal information that is unrelated to immediate sensory input.
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