ArticleProceedings of the National Academy of Sciences of the United States of America2016
Community deworming alleviates geohelminth-induced immune hyporesponsiveness.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Public health deworming programmes for soil-transmitted helminths in children living in endemic areas.The Cochrane database of systematic reviews · 2019Pooled it
- Plasmodium and intestinal parasite perturbations of the infected host's inflammatory responses: a systematic review.Parasites & vectors · 2018Pooled it
- The Impact of Intensive Versus Standard Anthelminthic Treatment on Allergy-related Outcomes, Helminth Infection Intensity, and Helminth-related Morbidity in Lake Victoria Fishing Communities, Uganda: Results From the LaVIISWA Cluster-randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Trial
- Dynamic changes in human-gut microbiome in relation to a placebo-controlled anthelminthic trial in Indonesia.PLoS neglected tropical diseases · 2018Trial
- Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia.Microbiome · 2018Trial
- Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria.BMC medicine · 2026Article
- The human immunome in the post-schistosomiasis mass drug administration era.PLoS neglected tropical diseases · 2026Review
- Developmental plasticity enables an intestinal tapeworm to adapt to dietary stress.Nature communications · 2026Article
- The endemic dilemma: why whole sporozoite malaria vaccine efficacy falls in the field.Trends in parasitology · 2026Review
- Status of cryptosporidiosis in cattle raised by marginalized nomadic communities of Southern Punjab, Pakistan: an observational study.Frontiers in veterinary science · 2026Article
- Prevalence and Infection Intensity of Soil-Transmitted Helminths and Schistosomiasis Among Preschool Children in Mainland Tanzania.Journal of parasitology research · 2026Article
- Experimental evolution of Plasmodium yoelii in single and helminth-coinfected mice.Malaria journal · 2025Article
- Prevalence and risk factors for parasitic infections among internally displaced persons in the North-Central Geopolitical Zone of Nigeria.BMC infectious diseases · 2025Article
- Article
- Lifestyle score is associated with cellular immune profiles in healthy Tanzanian adults.Brain, behavior, & immunity - health · 2024Article
- Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024Review
- The amalgam of naive CD4Immunity · 2024Article
- Humans seropositive for Trypanosoma cruzi co-infected with intestinal helminths have higher infectiousness, parasitaemia and Th2-type response in the Argentine Chaco.Parasites & vectors · 2024Article
- Immunological factors linked to geographical variation in vaccine responses.Nature reviews. Immunology · 2024Review
- Infection with soil-transmitted helminths and their impact on coinfections.Frontiers in parasitology · 2023Review
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cross-sectional studies, chronic helminth infections have been associated with immunological hyporesponsiveness that can affect responses to unrelated antigens. To study the immunological effects of deworming, we conducted a cluster-randomized, double-blind, placebo-controlled trial in Indonesia and assigned 954 households to receive albendazole or placebo once every 3 mo for 2 y. Helminth-specific and nonspecific whole-blood cytokine responses were assessed in 1,059 subjects of all ages, whereas phenotyping of regulatory molecules was undertaken in 121 school-aged children. All measurements were performed before and at 9 and 21 mo after initiation of treatment. Anthelmintic treatment resulted in significant increases in proinflammatory cytokine responses to Plasmodium falciparum-infected red blood cells (PfRBCs) and mitogen, with the largest effect on TNF responses to PfRBCs at 9 mo-estimate [95% confidence interval], 0.37 [0.21-0.53], P value over time (P
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.