ArticleProceedings of the National Academy of Sciences of the United States of America2016
Overdrinking, swallowing inhibition, and regional brain responses prior to swallowing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Syndrome of Inappropriate Antidiuresis: From Pathophysiology to Management.Endocrine reviews · 2023Review
- Periictal water drinking revisited: Occurrence and lateralizing value in surgically confirmed patients with focal epilepsy.Epilepsia open · 2023Article
- Rational regulation of water-seeking effort in rodents.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A Subset of Primary Polydipsia, "Dipsogneic Diabetes Insipidus", in Apparently Healthy People Due to Excessive Water Intake: Not Enough Light to Illuminate the Dark Tunnel.Healthcare (Basel, Switzerland) · 2021Review
- Primary polydipsia: Update.Best practice & research. Clinical endocrinology & metabolism · 2020Review
- Article
- Regional brain responses associated with using imagination to evoke and satiate thirst.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Thirst and Drinking Paradigms: Evolution from Single Factor Effects to Brainwide Dynamic Networks.Nutrients · 2019Review
- Review
- Factors Influencing Oral Intake Improvement and Feeding Tube Dependency in Patients with Poststroke Dysphagia.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Observational
- The Bed Nucleus of the Stria Terminalis, Homeostatic Satiety, and Compulsions: What Can We Learn From Polydipsia?Frontiers in behavioral neuroscience · 2019Article
- Influence of anterior midcingulate cortex on drinking behavior during thirst and following satiation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The neural basis of homeostatic and anticipatory thirst.Nature reviews. Nephrology · 2018Review
- Neural circuits underlying thirst and fluid homeostasis.Nature reviews. Neuroscience · 2017Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
In humans, drinking replenishes fluid loss and satiates the sensation of thirst that accompanies dehydration. Typically, the volume of water drunk in response to thirst matches the deficit. Exactly how this accurate metering is achieved is unknown; recent evidence implicates swallowing inhibition as a potential factor. Using fMRI, this study investigated whether swallowing inhibition is present after more water has been drunk than is necessary to restore fluid balance within the body. This proposal was tested using ratings of swallowing effort and measuring regional brain responses as participants prepared to swallow small volumes of liquid while they were thirsty and after they had overdrunk. Effort ratings provided unequivocal support for swallowing inhibition, with a threefold increase in effort after overdrinking, whereas addition of 8% (wt/vol) sucrose to water had minimal effect on effort before or after overdrinking. Regional brain responses when participants prepared to swallow showed increases in the motor cortex, prefrontal cortices, posterior parietal cortex, striatum, and thalamus after overdrinking, relative to thirst. Ratings of swallowing effort were correlated with activity in the right prefrontal cortex and pontine regions in the brainstem; no brain regions showed correlated activity with pleasantness ratings. These findings are all consistent with the presence of swallowing inhibition after excess water has been drunk. We conclude that swallowing inhibition is an important mechanism in the overall regulation of fluid intake in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.