Evidence map›Paper›PMID 27790386›Full record

ArticleIntravital2016

Validation of a device for the active manipulation of the tumor microenvironment during intravital imaging.

James K Williams, David Entenberg, Yarong Wang, Alvaro Avivar-Valderas, Michael Padgen, Ashley Clark, Julio A Aguirre-Ghiso, James Castracane, John S Condeelis

Open access · bronzeAbstract read
In one paragraph

Article in Intravital, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Multidimensional Imaging of Breast Cancer.Cold Spring Harbor perspectives in medicine · 2023
    Review
  2. Review
  3. Monitoring and modulation of the tumor microenvironment for enhanced cancer modeling.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
  4. Multiphoton intravital microscopy of rodents.Nature reviews. Methods primers · 2022
    Article
  5. Frontiers in Intravital Multiphoton Microscopy of Cancer.Cancer reports (Hoboken, N.J.) · 2020
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

James K WilliamsColleges of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY, USA.
David EntenbergGruss Lipper Biophotonics Center, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA; Integrated Imaging Program, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
Yarong WangDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA; Integrated Imaging Program, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
Alvaro Avivar-ValderasDepartment of Medicine and Department Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY, USA.
Michael PadgenColleges of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY, USA.
Ashley ClarkColleges of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY, USA.
Julio A Aguirre-GhisoDepartment of Medicine and Department Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY, USA.
James CastracaneColleges of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY, USA.
John S CondeelisGruss Lipper Biophotonics Center, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA; Integrated Imaging Program, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
SUNY Polytechnic Institute · USIcahn School of Medicine at Mount Sinai · USYeshiva University · USAlbert Einstein College of Medicine · US

Funding

Tumor Progression and MetastasisP01CA100324 · NCI · YESHIVA UNIVERSITY · PI CONDEELIS, JOHN S · 2003 to 2018
$30.0M
Functional Determinants of Metastatic DormancyR01CA109182 · NCI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI AGUIRRE-GHISO, JULIO A. · 2005 to 2025
$8.3M
Tumor microenvironments determing migration, dissemination and dormancyU54CA163131 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI AGUIRRE-GHISO, JULIO A., CASTRACANE, JAMES · 2011 to 2015
$3.9M
NCI NIH HHS P01 CA100324NCI NIH HHS R01 CA109182NCI NIH HHS U54 CA163131
6 · The paper itself

Abstract

The tumor microenvironment is recognized as playing a significant role in the behavior of tumor cells and their progression to metastasis. However, tools to manipulate the tumor microenvironment directly, and image the consequences of this manipulation with single cell resolution in real time

Indexed as

chemotaxishypoxiaintravital imagingmetastasis

Identifiers

PMID27790386
PMCPMC5079288
OpenAlexW2345015523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.