Evidence map›Paper›PMID 27790378›Full record

ReviewBone research2016

Vitamin D, calcium homeostasis and aging.

Vaishali Veldurthy, Ran Wei, Leyla Oz, Puneet Dhawan, Yong Heui Jeon, Sylvia Christakos

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 2 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 2 syntheses or guidelines pooled it, 350 citations in OpenAlex.

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  11. [Interpretation of the Expert Consensus Statement on the Role of Vitamin D in Metabolic Health].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vaishali VeldurthyDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School , Newark, NJ 07103, USA.
Ran WeiDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School , Newark, NJ 07103, USA.
Leyla OzDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School , Newark, NJ 07103, USA.
Puneet DhawanDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School , Newark, NJ 07103, USA.
Yong Heui JeonDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School , Newark, NJ 07103, USA.
Sylvia ChristakosDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School , Newark, NJ 07103, USA.
Rutgers, The State University of New Jersey · US

Funding

Osteoporosis and Molecular Targets of Vitamin DR21AG044552 · NIA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CHRISTAKOS, SYLVIA S · 2014 to 2015
$354k
NIA NIH HHS R21 AG044552
6 · The paper itself

Abstract

Osteoporosis is characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. Evidence is accumulating for an important role of calcium deficiency as the process of aging is associated with disturbed calcium balance. Vitamin D is the principal factor that maintains calcium homeostasis. Increasing evidence indicates that the reason for disturbed calcium balance with age is inadequate vitamin D levels in the elderly. In this article, an overview of our current understanding of vitamin D, its metabolism, and mechanisms involved in vitamin D-mediated maintenance of calcium homeostasis is presented. In addition, mechanisms involved in age-related dysregulation of 1,25(OH)

Identifiers

PMID27790378
PMCPMC5068478
OpenAlexW2536610984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.