Evidence map›Paper›PMID 27790217›Full record

ArticleFrontiers in immunology2016

Cholinergic Stimulation Prevents the Development of Autoimmune Diabetes: Evidence for the Modulation of Th17 Effector Cells via an IFNγ-Dependent Mechanism.

Junu A George, Ghada Bashir, Mohammed M Qureshi, Yassir A Mohamed, Jamil Azzi, Basel K Al-Ramadi, Maria J Fernández-Cabezudo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

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  12. Effectiveness of Antihyperglycemic Effect ofEvidence-based complementary and alternative medicine : eCAM · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Junu A GeorgeDepartment of Biochemistry, College of Medicine and Health Sciences, United Arab University , Al-Ain , UAE.
Ghada BashirDepartment of Medical Microbiology & Immunology, College of Medicine and Health Sciences, United Arab University , Al-Ain , UAE.
Mohammed M QureshiDepartment of Biochemistry, College of Medicine and Health Sciences, United Arab University , Al-Ain , UAE.
Yassir A MohamedDepartment of Medical Microbiology & Immunology, College of Medicine and Health Sciences, United Arab University , Al-Ain , UAE.
Jamil AzziRenal Division, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
Basel K Al-RamadiDepartment of Medical Microbiology & Immunology, College of Medicine and Health Sciences, United Arab University , Al-Ain , UAE.
Maria J Fernández-CabezudoDepartment of Biochemistry, College of Medicine and Health Sciences, United Arab University , Al-Ain , UAE.
United Arab Emirates University · AEBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type I diabetes (T1D) results from T cell-mediated damage of pancreatic β-cells and loss of insulin production. The cholinergic anti-inflammatory pathway represents a physiological link connecting the central nervous and immune systems

Indexed as

acetylcholineIFNγinhibition of AChEneuroimmunologyTh17type I diabetes

Identifiers

PMID27790217
PMCPMC5061850
OpenAlexW2530263455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.