Evidence map›Paper›PMID 27790141›Full record

ReviewFrontiers in pharmacology2016

Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?

Graziamaria Corbi, Valeria Conti, Sergio Davinelli, Giovanni Scapagnini, Amelia Filippelli, Nicola Ferrara

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  17. Effects of the Essential Oil fromMolecules (Basel, Switzerland) · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Graziamaria CorbiDepartment of Medicine and Health Sciences, University of Molise Campobasso, Italy.
Valeria ContiDepartment of Medicine, Surgery and Dentistry, University of Salerno Salerno, Italy.
Sergio DavinelliDepartment of Medicine and Health Sciences, University of Molise Campobasso, Italy.
Giovanni ScapagniniDepartment of Medicine and Health Sciences, University of Molise Campobasso, Italy.
Amelia FilippelliDepartment of Medicine, Surgery and Dentistry, University of Salerno Salerno, Italy.
Nicola FerraraDepartment of Translational Medical Sciences, Federico II University of NaplesNaples, Italy; Salvatore Maugeri Foundation, IRCCS, Scientific Institute of TeleseTelese Terme, Italy.
University of Molise · ITUniversity of Salerno · ITFondazione Salvatore Maugeri · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although several efforts have been made in the search for genetic and epigenetic patterns linked to diseases, a comprehensive explanation of the mechanisms underlying pathological phenotypic plasticity is still far from being clarified. Oxidative stress and inflammation are two of the major triggers of the epigenetic alterations occurring in chronic pathologies, such as neurodegenerative diseases. In fact, over the last decade, remarkable progress has been made to realize that chronic, low-grade inflammation is one of the major risk factor underlying brain aging. Accumulated data strongly suggest that phytochemicals from fruits, vegetables, herbs, and spices may exert relevant immunomodulatory and/or anti-inflammatory activities in the context of brain aging. Starting by the evidence that a common denominator of aging and chronic degenerative diseases is represented by inflammation, and that several dietary phytochemicals are able to potentially interfere with and regulate the normal function of cells, in particular neuronal components, aim of this review is to summarize recent studies on neuroinflammaging processes and proofs indicating that specific phytochemicals may act as positive modulators of neuroinflammatory events. In addition, critical pathways involved in mediating phytochemicals effects on neuroinflammaging were discussed, exploring the real impact of these compounds in preserving brain health before the onset of symptoms leading to inflammatory neurodegeneration and cognitive decline.

Indexed as

antioxidantscurcuminNfr2resveratrolsirtuins

Identifiers

PMID27790141
PMCPMC5062465
OpenAlexW2531031657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.