ReviewFrontiers in behavioral neuroscience2016
Adolescent Maturational Transitions in the Prefrontal Cortex and Dopamine Signaling as a Risk Factor for the Development of Obesity and High Fat/High Sugar Diet Induced Cognitive Deficits.
Review in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Examining Adolescence as a Sensitive Period for High-Fat, High-Sugar Diet Exposure: A Systematic Review of the Animal Literature.Frontiers in neuroscience · 2019Pooled it
- Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans.Cell metabolism · 2020Trial
- Pilot randomized controlled trial of a mindfulness-based group intervention in adolescent girls at risk for type 2 diabetes with depressive symptoms.Complementary therapies in medicine · 2017Trial
- Intermittency and Predictability of a Cafeteria Diet Shape Food Intake, Adiposity, and Neurobehavioral Outcomes in Rats.Nutrients · 2026Article
- Association of serum biomarkers for lipid and amino acid metabolism with cognition in adolescents.Pediatric research · 2026Article
- Evaluating bidirectional, longitudinal associations between adolescent executive control and eating behaviors.Appetite · 2026Article
- The Impact of Upward Social Comparison on Smartphone Addiction Among Adolescents: The Moderating Role of Football Participation.Behavioral sciences (Basel, Switzerland) · 2026Article
- Integrating Cancer Prevention into Science Education: Development of the CARES4You School-based Curriculum.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025Article
- Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer.Molecular biomedicine · 2025Review
- Effects of Adolescent Social Isolation on PFC's β-Catenin Levels and Anxiety-Like Behaviors in Male and Female Rats: Study of the Role of Dopaminergic D2 Receptors.Journal of molecular neuroscience : MN · 2025Article
- Leveraging Social Media Data to Understand the Impact of COVID-19 on Residents' Dietary Behaviors: Observational Study.Journal of medical Internet research · 2025Observational
- Food Intake and Mental Health Among Middle School Students in Shandong Province: A Network Analysis.Psychology research and behavior management · 2025Article
- Validity and Reliability of the Transcultural Arabic Adaptation of the Food-Mood Questionnaire Among College Students.International journal of environmental research and public health · 2024Article
- The Interaction Between Attention Deficit and Hyperactivity Disorder and Nutrition.Current nutrition reports · 2024Review
- Soy-Based High-Protein Spheric Foods with the Appearance of Familiar Sugary Snacks.Foods (Basel, Switzerland) · 2024Article
- The interconnection between obesity and executive function in adolescence: The role of the gut microbiome.Neuroscience and biobehavioral reviews · 2023Review
- Effects of aerobic exercise training in oxidative metabolism and mitochondrial biogenesis markers on prefrontal cortex in obese mice.BMC sports science, medicine & rehabilitation · 2022Article
- [Effects of overweight and obesity on cognitive functions of children and adolescents].Revista de neurologia · 2022Review
- The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period.Frontiers in neural circuits · 2022Review
- Odor-Taste-Texture Interactions as a Promising Strategy to Tackle Adolescent Overweight.Nutrients · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adolescence poses as both a transitional period in neurodevelopment and lifestyle practices. In particular, the developmental trajectory of the prefrontal cortex (PFC), a critical region for behavioral control and self-regulation, is enduring, not reaching functional maturity until the early 20 s in humans. Furthermore, the neurotransmitter dopamine is particularly abundant during adolescence, tuning the brain to rapidly learn about rewards and regulating aspects of neuroplasticity. Thus, adolescence is proposed to represent a period of vulnerability towards reward-driven behaviors such as the consumption of palatable high fat and high sugar diets. This is reflected in the increasing prevalence of obesity in children and adolescents as they are the greatest consumers of "junk foods". Excessive consumption of diets laden in saturated fat and refined sugars not only leads to weight gain and the development of obesity, but experimental studies with rodents indicate they evoke cognitive deficits in learning and memory process by disrupting neuroplasticity and altering reward processing neurocircuitry. Consumption of these high fat and high sugar diets have been reported to have a particularly pronounced impact on cognition when consumed during adolescence, demonstrating a susceptibility of the adolescent brain to enduring cognitive deficits. The adolescent brain, with heightened reward sensitivity and diminished behavioral control compared to the mature adult brain, appears to be a risk for aberrant eating behaviors that may underpin the development of obesity. This review explores the neurodevelopmental changes in the PFC and mesocortical dopamine signaling that occur during adolescence, and how these potentially underpin the overconsumption of palatable food and development of obesogenic diet-induced cognitive deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.