Evidence map›Paper›PMID 27790080›Full record

ArticleAdvanced functional materials2016

Magnetic Nanoparticle Facilitated Drug Delivery for Cancer Therapy with Targeted and Image-Guided Approaches.

Jing Huang, Yuancheng Li, Anamaria Orza, Qiong Lu, Peng Guo, Liya Wang, Lily Yang, Hui Mao

Abstract read
In one paragraph

Article in Advanced functional materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Advances in Smart Responsive Nanofibers for Wound Healing.Biomimetics (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Mussel-Bioinspired Edible CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. pH-responsive magnetic FeMaterials today. Bio · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Enhanced Ferroelectric Polarization in Au@BaTiOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing HuangDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Yuancheng LiDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Anamaria OrzaDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Qiong LuDepartment of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Peng GuoDepartment of Biomedical Engineering, The City College of New York, New York, NY 10031, USA. Vascular Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.
Liya WangDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Lily YangDepartment of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Hui MaoDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.

Funding

Stroma Breaking Theranostic Nanoparticle for Targeted Pancreatic Cancer TherapyU01CA198913 · NCI · EMORY UNIVERSITY · PI MAO, HUI, YANG, LILY · 2015 to 2019
$3.0M
Theranostic Nano particles for Targeted Treatment of Pancreatic CancerU01CA151810 · NCI · EMORY UNIVERSITY · PI MAO, HUI, YANG, LILY · 2010 to 2014
$2.2M
MRI Capable Receptor Targeted Drug Delivery for Pancreatic CancerR01CA154846 · NCI · EMORY UNIVERSITY · PI MAO, HUI, YANG, LILY · 2011 to 2015
$2.1M
NCI NIH HHS R01 CA154846NCI NIH HHS U01 CA151810NCI NIH HHS U01 CA198913
6 · The paper itself

Abstract

With rapid advances in nanomedicine, magnetic nanoparticles (MNPs) have emerged as a promising theranostic tool in biomedical applications, including diagnostic imaging, drug delivery and novel therapeutics. Significant preclinical and clinical research has explored their functionalization, targeted delivery, controllable drug release and image-guided capabilities. To further develop MNPs for theranostic applications and clinical translation in the future, we attempt to provide an overview of the recent advances in the development and application of MNPs for drug delivery, specifically focusing on the topics concerning the importance of biomarker targeting for personalized therapy and the unique magnetic and contrast-enhancing properties of theranostic MNPs that enable image-guided delivery. The common strategies and considerations to produce theranostic MNPs and incorporate payload drugs into MNP carriers are described. The notable examples are presented to demonstrate the advantages of MNPs in specific targeting and delivering under image guidance. Furthermore, current understanding of delivery mechanisms and challenges to achieve efficient therapeutic efficacy or diagnostic capability using MNP-based nanomedicine are discussed.

Identifiers

PMID27790080
PMCPMC5077153

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.