ReviewOpen access rheumatology : research and reviews2011
Genetics of rheumatoid arthritis: GWAS and beyond.
Review in Open access rheumatology : research and reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Intra-articular injection of etanercept versus glucocorticoids in rheumatoid arthritis patients.Clinical rheumatology · 2021Trial
- The Association between Inefficient Repair of DNA Double-Strand Breaks and Common Polymorphisms of the HRR and NHEJ Repair Genes in Patients with Rheumatoid Arthritis.International journal of molecular sciences · 2024Article
- Article
- Robust SNP-based prediction of rheumatoid arthritis through machine-learning-optimized polygenic risk score.Journal of translational medicine · 2023Article
- Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid.Cellular & molecular biology letters · 2022Review
- Gene Interaction Network Analysis Reveals IFI44L as a Drug Target in Rheumatoid Arthritis and Periodontitis.Molecules (Basel, Switzerland) · 2022Article
- Association of the DNASE1L3 rs35677470 polymorphism with systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis: Structural biological insights.Molecular medicine reports · 2020Article
- Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis.Cells · 2020Review
- Rheumatological manifestations in inborn errors of immunity.Pediatric research · 2020Review
- Inferring the Nature of Missing Heritability in Human Traits Using Data from the GWAS Catalog.Genetics · 2019Article
- Systematic approach demonstrates enrichment of multiple interactions between non-Annals of the rheumatic diseases · 2018Article
- Genetics of rheumatoid arthritis susceptibility, severity, and treatment response.Seminars in immunopathology · 2017Review
- Association of the Smad3 and NFATc2 gene polymorphisms and their serum levels with susceptibility to rheumatoid arthritis in Polish cohorts.Clinical and experimental immunology · 2015Article
- Modulation of peripheral T-cell function by interleukin-7 in rheumatoid arthritis.Arthritis research & therapy · 2014Article
- Targeted exon sequencing fails to identify rare coding variants with large effect in rheumatoid arthritis.Arthritis research & therapy · 2014Article
- Gene expression analysis in RA: towards personalized medicine.The pharmacogenomics journal · 2014Review
- Genetics and epigenetics of rheumatoid arthritis.Nature reviews. Rheumatology · 2013Review
- PUMA: a unified framework for penalized multiple regression analysis of GWAS data.PLoS computational biology · 2013Article
- Strong Association of Polymorphism inAvicenna journal of medical biotechnologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of complex genetics in autoimmune diseases has progressed at a tremendous pace over the last 4 years, as a direct result of the enormous gains made by genome wide association studies (GWAS). Novel genetic findings are continuously being reported alongside the rapid development of genetic technologies, sophisticated statistical analysis, and larger sample collections. It is now becoming clear that multiple genes contribute to disease risk in many complex genetic disorders including rheumatoid arthritis (RA) and that there are common genetic risk factors that underlie a spectrum of autoimmune diseases. This review details the current genetic landscape of RA, and describes what GWAS has taught us in terms of missing heritability, subsets of disease, existence of genetic heterogeneity, and shared autoimmune risk loci. Finally, this review addresses the initial challenges faced in translating the wealth of genetic findings into determining the biological mechanisms that contribute to the relationship between genotype and phenotype. Unraveling the mechanism of how genes directly influence the cause of RA will lead to a better understanding of the disease and will ultimately have a direct clinical impact, informing the development of new therapies that can be utilized in the treatment of RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.