ReviewNeuropsychiatric disease and treatment2016
Changes in behavior as side effects in methylphenidate treatment: review of the literature.
Review in Neuropsychiatric disease and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Serum GDF-15 Levels in Pediatric ADHD: Associations with Symptom Severity and Stimulant Exposure.Neuropsychiatric disease and treatment · 2026Article
- Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake.Investigative ophthalmology & visual science · 2025Article
- ADHD and Suicide Risk: The Overlooked Roles of Comorbid Disorders and Stimulant Medications.Clinical neuropsychiatry · 2025Article
- Reevaluating ADHD and its First-Line Treatment: Insights from DSM-5-TR and Modern Approaches.Clinical neuropsychiatry · 2024Article
- Chronic Methylphenidate Effects on Brain Gene Expression: An Exploratory Review.Psychology research and behavior management · 2024Review
- Individually tailored dosage regimen of full-spectrum Cannabis extracts for autistic core and comorbid symptoms: a real-life report of multi-symptomatic benefits.Frontiers in psychiatry · 2023Article
- Overdiagnosis of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents: A Systematic Scoping Review.JAMA network open · 2021Article
- Cognitive Enhancement: Unanswered Questions About Human Psychology and Social Behavior.Science and engineering ethics · 2021Article
- Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects.Developmental psychobiology · 2020Article
- Ventral striatum supports Methylphenidate therapeutic effects on impulsive choices expressed in temporal discounting task.Scientific reports · 2020Article
- Use of Methylphenidate in Excessive Daytime Sleepiness in Alzheimer's Patients Treated with Donepezil: Case Series.Neuropsychiatric disease and treatment · 2020Article
- Methylphenidate Dose-Dependently Affects Aggression and Improves Fear Extinction and Anxiety in BALB/cJ Mice.Frontiers in psychiatry · 2019Article
- Methylphenidate-Induced Psychotic Symptoms in 65-Year-Old Female with ADHD.Iranian journal of psychiatry · 2018Article
- Six months methylphenidate treatment improves emotion dysregulation in adolescents with attention deficit/hyperactivity disorder: a prospective study.Neuropsychiatric disease and treatment · 2018Article
- Methylphenidate causes chronic eosinophilic pneumonia.Annals of thoracic medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur review of the scientific literature focused on an analysis of studies describing instances of methylphenidate treatment leading (or not) to behavioral changes in the pediatric, adolescent, and adult populations. MATERIALS AND
methodsWe conducted a literature search in PubMed, Medline, and Google using the keywords "methylphenidate", "behavioral changes", "adverse effects", and "side effects". A total of 44 studies were identified as reporting on the effects and adverse effects of methylphenidate administration, and were included in the analysis.
resultsFive studies specifically set out to study, record, and discuss changes in behavior. Eight studies did not set out to study behavioral effects, but record and discuss them. A total of 28 studies recorded behavioral effects, but failed to discuss these further. Three studies did not include behavioral effects.
conclusionThis review records what data have been published in respect of changes in behavior in association with the use of methylphenidate. While there is some evidence to suggest that methylphenidate causes changes in behavior, the majority of the studies reviewed paid little or no attention to this issue. Based on the available data, it is impossible to determine the point at which such behavioral effects occur. The frequency of occurrence of behavioral effects is also impossible to determine with certainty. Based on the available data, it is not possible to rule out whether behavioral effects may persist or not persist once treatment is discontinued. In conclusion, despite countless publications and extensive administration, especially to children, we have insufficient data to judge the long-term effects and risks of methylphenidate taking.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.