ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Blunted increases in skin sympathetic nerve activity are related to attenuated reflex vasodilation in aged human skin.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of vehicle microdialysis solutions on cutaneous vascular responses to local heating.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- The physiology of survival: Heat.Experimental physiology · 2026Article
- Heat Tolerance in Older Adults: A Systematic Review of Thermoregulation, Vulnerability, Environmental Change, and Health Outcomes.Healthcare (Basel, Switzerland) · 2025Review
- Cardiovascular challenges of aging in a hotter environment: a narrative review.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Development & application of a wearable non-differential calorimeter for skin heat transfer analysis.PloS one · 2025Article
- Human temperature regulation under heat stress in health, disease, and injury.Physiological reviews · 2022Review
- Temperature regulation during exercise in the heat: Insights for the aging athlete.Journal of science and medicine in sport · 2021Review
- Thermoregulatory reflex control of cutaneous vasodilation in healthy aging.Temperature (Austin, Tex.) · 2021Article
- Skin sympathetic nerve activity and ventricular rate control during atrial fibrillation.Heart rhythm · 2020Article
- Chronic statin therapy is associated with enhanced cutaneous vascular responsiveness to sympathetic outflow during passive heat stress.The Journal of physiology · 2019Article
- Aging and Thermoregulatory Control: The Clinical Implications of Exercising under Heat Stress in Older Individuals.BioMed research international · 2018Review
- Edward F. Adolph Distinguished Lecture: Skin-deep insights into vascular aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Measuring and quantifying skin sympathetic nervous system activity in humans.Journal of neurophysiology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Reflex cutaneous vasodilation in response to passive heating is attenuated in human aging. This diminished response is mediated, in part, by age-associated reductions in endothelial function; however, the contribution of altered skin sympathetic nervous system activity (SSNA) is unknown. We hypothesized that 1) healthy older adults would demonstrate blunted SSNA responses to increased core temperature compared with young adults and 2) the decreased SSNA response would be associated with attenuated cutaneous vasodilation. Reflex vasodilation was elicited in 13 young [23 ± 1 (SE) yr] and 13 older (67 ± 2 yr) adults using a water-perfused suit to elevate esophageal temperature by 1.0°C. SSNA (peroneal microneurography) and red cell flux (laser Doppler flowmetry) in the innervated dermatome (the dorsum of foot) were continuously measured. SSNA was normalized to, and expressed as, a percentage of baseline. Cutaneous vascular conductance (CVC) was calculated as flux/mean arterial pressure and expressed as a percentage of maximal CVC (local heating, 43°C). Reflex vasodilation was attenuated in older adults (P < 0.001). During heating, SSNA increased in both groups (P < 0.05); however, the response was significantly blunted in older adults (P = 0.01). The increase in SSNA during heating was linearly related to cutaneous vasodilation in both young (R
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Registered trials
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