Evidence map›Paper›PMID 27789734›Full record

ArticlePhysiological genomics2017

Elevated K+ channel activity opposes vasoconstrictor response to serotonin in cerebral arteries of the Fawn Hooded Hypertensive rat.

Mallikarjuna R Pabbidi, Richard J Roman

Open access · hybridAbstract read
In one paragraph

Article in Physiological genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Knockout ofThe Journal of pharmacology and experimental therapeutics · 2021
    Article
  3. Review
  4. Serotonergic afferents from the dorsal raphe decrease the excitability of pyramidal neurons in the anterior piriform cortex.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  5. Calcium- and voltage-gated BK channels in vascular smooth muscle.Pflugers Archiv : European journal of physiology · 2018
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mallikarjuna R PabbidiDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi mpabbidi@umc.edu.
Richard J RomanDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
University of Mississippi Medical Center · US

Funding

Modification of Vascular Signaling in the Brain by ROSR01HL092105 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HARDER, DAVID RAE · 2009 to 2013
$2.0M
Renal microcirculation and hypertension induced renal injuryR01DK104184 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2014 to 2017
$1.8M
NHLBI NIH HHS R01 HL092105NIDDK NIH HHS R01 DK104184
6 · The paper itself

Abstract

Previous studies suggest that middle cerebral arteries (MCAs) of Fawn Hooded Hypertensive (FHH) rats exhibit impaired myogenic response and introgression of a small region of Brown Norway chromosome 1 containing 15 genes restored the response in FHH.1

Indexed as

AnimalsCalcium SignalingCells, CulturedCerebral ArteriesDisease Models, AnimalHypertensionIon Channel GatingLarge-Conductance Calcium-Activated Potassium ChannelsMaleMembrane PotentialsMuscle, Smooth, VascularRatsRats, Inbred BNRats, Inbred SHRReceptors, SerotoninSerotoninLarge-Conductance Calcium-Activated Potassium ChannelsReceptors, SerotoninSerotoninSerotonin Receptor AgonistscalciumK+ channelsmyogenic responseserotonin (5-HT)

Identifiers

PMID27789734
PMCPMC5283921
OpenAlexW2539737681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.