ArticleNucleic acids research2017
Updates in Rhea - an expert curated resource of biochemical reactions.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
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- The automated Galaxy-SynBioCAD pipeline for synthetic biology design and engineering.Nature communications · 2022Article
- Design and application of a knowledge network for automatic prioritization of drug mechanisms.Bioinformatics (Oxford, England) · 2022Article
- Redefining the coenzyme A transferase superfamily with a large set of manually annotated proteins.Protein science : a publication of the Protein Society · 2022Article
- Review
- An overview of graph databases and their applications in the biomedical domain.Database : the journal of biological databases and curation · 2021Article
- First Genome-Scale Metabolic Model ofMetabolites · 2021Article
- MetaNetX/MNXref: unified namespace for metabolites and biochemical reactions in the context of metabolic models.Nucleic acids research · 2021Article
- Review on the Computational Genome Annotation of Sequences Obtained by Next-Generation Sequencing.Biology · 2020Review
- novoPathFinder: a webserver of designing novel-pathway with integrating GEM-model.Nucleic acids research · 2020Article
- Enzyme annotation in UniProtKB using Rhea.Bioinformatics (Oxford, England) · 2020Article
- MicroScope: an integrated platform for the annotation and exploration of microbial gene functions through genomic, pangenomic and metabolic comparative analysis.Nucleic acids research · 2020Article
- A Coordinated Approach by Public Domain Bioinformatics Resources to Aid the Fight Against Alzheimer's Disease Through Expert Curation of Key Protein Targets.Journal of Alzheimer's disease : JAD · 2020Article
- Metabolic Modeling of Streptococcus mutans Reveals Complex Nutrient Requirements of an Oral Pathogen.mSystems · 2019Article
- A Bioinformatics View of Glycan⁻Virus Interactions.Viruses · 2019Review
- Updates in Rhea: SPARQLing biochemical reaction data.Nucleic acids research · 2019Article
- RetroRules: a database of reaction rules for engineering biology.Nucleic acids research · 2019Article
- A genome-scale metabolic network reconstruction of extremely halophilic bacterium Salinibacter ruber.PloS one · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhea (http://www.rhea-db.org) is a comprehensive and non-redundant resource of expert-curated biochemical reactions designed for the functional annotation of enzymes and the description of metabolic networks. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions, using entities from the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules. Here we describe developments in Rhea since our last report in the database issue of Nucleic Acids Research. These include the first implementation of a simple hierarchical classification of reactions, improved coverage of the IUBMB Enzyme Nomenclature list and additional reactions through continuing expert curation, and the development of a new website to serve this improved dataset.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.