Evidence map›Paper›PMID 27789476›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2016

Cross-Sectional Associations of Flow Reversal, Vascular Function, and Arterial Stiffness in the Framingham Heart Study.

Rosa Bretón-Romero, Na Wang, Joseph Palmisano, Martin G Larson, Ramachandran S Vasan, Gary F Mitchell, Emelia J Benjamin, Joseph A Vita, Naomi M Hamburg

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

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  12. Aortic stiffness, pressure and flow pulsatility, and target organ damage.Journal of applied physiology (Bethesda, Md. : 1985) · 2018
    Review
  13. Article
  14. Article
  15. Killing Me Unsoftly: Causes and Mechanisms of Arterial Stiffness.Arteriosclerosis, thrombosis, and vascular biology · 2017
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Rosa Bretón-RomeroFrom the Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study (M.G.L., R.S.V., E.J.B.), MA; Cardiology (R.S.V., E.J.B., J.A.V., N.M.H.) and Preventive Medicine Sections (R.S.V., E.J.B.), and Whitaker Cardiovascular Institute, School of Medicine (R.B.-R., R.S.V., E.J.B., J.A.V., N.M.H.), School of Public Health (N.W., J.P., M.G.L., R.S.V., E.J.B.), and Departments of Mathematics and Statistics (M.G.L.), Boston University, MA; and Cardiovascular Engineering Inc, Norwood, MA (G.F.M.).
Na WangFrom the Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study (M.G.L., R.S.V., E.J.B.), MA; Cardiology (R.S.V., E.J.B., J.A.V., N.M.H.) and Preventive Medicine Sections (R.S.V., E.J.B.), and Whitaker Cardiovascular Institute, School of Medicine (R.B.-R., R.S.V., E.J.B., J.A.V., N.M.H.), School of Public Health (N.W., J.P., M.G.L., R.S.V., E.J.B.), and Departments of Mathematics and Statistics (M.G.L.), Boston University, MA; and Cardiovascular Engineering Inc, Norwood, MA (G.F.M.).
Joseph PalmisanoFrom the Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study (M.G.L., R.S.V., E.J.B.), MA; Cardiology (R.S.V., E.J.B., J.A.V., N.M.H.) and Preventive Medicine Sections (R.S.V., E.J.B.), and Whitaker Cardiovascular Institute, School of Medicine (R.B.-R., R.S.V., E.J.B., J.A.V., N.M.H.), School of Public Health (N.W., J.P., M.G.L., R.S.V., E.J.B.), and Departments of Mathematics and Statistics (M.G.L.), Boston University, MA; and Cardiovascular Engineering Inc, Norwood, MA (G.F.M.).
Martin G LarsonFrom the Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study (M.G.L., R.S.V., E.J.B.), MA; Cardiology (R.S.V., E.J.B., J.A.V., N.M.H.) and Preventive Medicine Sections (R.S.V., E.J.B.), and Whitaker Cardiovascular Institute, School of Medicine (R.B.-R., R.S.V., E.J.B., J.A.V., N.M.H.), School of Public Health (N.W., J.P., M.G.L., R.S.V., E.J.B.), and Departments of Mathematics and Statistics (M.G.L.), Boston University, MA; and Cardiovascular Engineering Inc, Norwood, MA (G.F.M.).
Ramachandran S VasanFrom the Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study (M.G.L., R.S.V., E.J.B.), MA; Cardiology (R.S.V., E.J.B., J.A.V., N.M.H.) and Preventive Medicine Sections (R.S.V., E.J.B.), and Whitaker Cardiovascular Institute, School of Medicine (R.B.-R., R.S.V., E.J.B., J.A.V., N.M.H.), School of Public Health (N.W., J.P., M.G.L., R.S.V., E.J.B.), and Departments of Mathematics and Statistics (M.G.L.), Boston University, MA; and Cardiovascular Engineering Inc, Norwood, MA (G.F.M.).
Gary F MitchellFrom the Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study (M.G.L., R.S.V., E.J.B.), MA; Cardiology (R.S.V., E.J.B., J.A.V., N.M.H.) and Preventive Medicine Sections (R.S.V., E.J.B.), and Whitaker Cardiovascular Institute, School of Medicine (R.B.-R., R.S.V., E.J.B., J.A.V., N.M.H.), School of Public Health (N.W., J.P., M.G.L., R.S.V., E.J.B.), and Departments of Mathematics and Statistics (M.G.L.), Boston University, MA; and Cardiovascular Engineering Inc, Norwood, MA (G.F.M.).
Emelia J BenjaminFrom the Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study (M.G.L., R.S.V., E.J.B.), MA; Cardiology (R.S.V., E.J.B., J.A.V., N.M.H.) and Preventive Medicine Sections (R.S.V., E.J.B.), and Whitaker Cardiovascular Institute, School of Medicine (R.B.-R., R.S.V., E.J.B., J.A.V., N.M.H.), School of Public Health (N.W., J.P., M.G.L., R.S.V., E.J.B.), and Departments of Mathematics and Statistics (M.G.L.), Boston University, MA; and Cardiovascular Engineering Inc, Norwood, MA (G.F.M.).
Joseph A VitaFrom the Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study (M.G.L., R.S.V., E.J.B.), MA; Cardiology (R.S.V., E.J.B., J.A.V., N.M.H.) and Preventive Medicine Sections (R.S.V., E.J.B.), and Whitaker Cardiovascular Institute, School of Medicine (R.B.-R., R.S.V., E.J.B., J.A.V., N.M.H.), School of Public Health (N.W., J.P., M.G.L., R.S.V., E.J.B.), and Departments of Mathematics and Statistics (M.G.L.), Boston University, MA; and Cardiovascular Engineering Inc, Norwood, MA (G.F.M.).
Naomi M HamburgFrom the Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study (M.G.L., R.S.V., E.J.B.), MA; Cardiology (R.S.V., E.J.B., J.A.V., N.M.H.) and Preventive Medicine Sections (R.S.V., E.J.B.), and Whitaker Cardiovascular Institute, School of Medicine (R.B.-R., R.S.V., E.J.B., J.A.V., N.M.H.), School of Public Health (N.W., J.P., M.G.L., R.S.V., E.J.B.), and Departments of Mathematics and Statistics (M.G.L.), Boston University, MA; and Cardiovascular Engineering Inc, Norwood, MA (G.F.M.). nhamburg@bu.edu.
Framingham Heart Study · USNational Heart Lung and Blood Institute · USNorwood Hospital · US

Funding

Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
Redox regulation in Endothelial Progenitor CellsP01HL081587 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN · 2005 to 2015
$21.5M
Framingham: Inflammation, Genes &Cardiovascular DiseaseR01HL076784 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2004 to 2008
$3.9M
Boston University Medical Center Leadership Program in Vascular MedicineK12HL083781 · NHLBI · BOSTON MEDICAL CENTER · PI EBERHARDT, ROBERT THOMAS · 2007 to 2013
$3.4M
Ventricular Vascular Coupling: Correlates and PrognosisR01HL080124 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2005 to 2009
$3.4M
Mitochondrial Dynamics and UCP2 - Endothelial Dysfunction in Human ObesityR01HL115391 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM · 2013 to 2017
$2.8M
Vascular Stiffness as a Precursor of Hypertension in a Middle-aged CohortR01HL126136 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2015 to 2018
$2.6M
Aortic Dysfunction, Pulsatile Stress and Target Organ Damage in FraminghamR01HL107385 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2011 to 2014
$2.6M
Vascular Function in the Framingham Third GenerationR01HL070100 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2002 to 2005
$2.4M
Endothelial Insulin Resistance, Inflammation and Vascular Function in DiabetesR01HL102299 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM · 2010 to 2014
$2.0M
Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham StudyR01AG028321 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2006 to 2010
$1.8M
ASYMPTOMATIC LEFT VENTRICULAR DYSFUNCTIONK24HL004334 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2001 to 2008
$707k
NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K12 HL083781NHLBI NIH HHS K24 HL004334NHLBI NIH HHS N01 HC025195NHLBI NIH HHS P01 HL081587NHLBI NIH HHS R01 HL060040NHLBI NIH HHS R01 HL070100NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01 HL080124NHLBI NIH HHS R01 HL102299NHLBI NIH HHS R01 HL107385NHLBI NIH HHS R01 HL115391NHLBI NIH HHS R01 HL126136NIA NIH HHS P30 AG013846NIA NIH HHS R01 AG028321
6 · The paper itself

Abstract

objectiveExperimental studies link oscillatory flow accompanied by flow reversal to impaired endothelial cell function. The relation of flow reversal with vascular function and arterial stiffness remains incompletely defined. APPROACH AND

resultsWe measured brachial diastolic flow patterns along with vasodilator function in addition to tonometry-based central and peripheral arterial stiffness in 5708 participants (age 47±13 years, 53% women) in the Framingham Heart Study Offspring and Third Generation cohorts. Brachial artery diastolic flow reversal was present in 35% of the participants. In multivariable regression models, the presence of flow reversal was associated with lower flow-mediated dilation (3.9±0.2 versus 5.0±0.2%; P<0.0001) and reactive hyperemic flow velocity (50±0.99 versus 57±0.93 cm/s; P<0.0001). The presence of flow reversal (compared with absence) was associated with higher central aortic stiffness (carotid-femoral pulse wave velocity 9.3±0.1 versus 8.9±0.1 m/s), lower muscular artery stiffness (carotid-radial pulse wave velocity 9.6±0.1 versus 9.8±0.1 m/s), and higher forearm vascular resistance (5.32±0.03 versus 4.66±0.02 log dyne/s/cm

conclusionsIn our large, community-based sample, brachial artery flow reversal was common and associated with impaired vasodilator function and higher aortic stiffness. Our findings are consistent with the concept that flow reversal may contribute to vascular dysfunction.

Indexed as

Pulsatile FlowVascular StiffnessVasodilationAdultAgedAortaBlood Flow VelocityBrachial ArteryCardiovascular DiseasesCross-Sectional StudiesEndothelium, VascularFemaleForearmHumansHyperemiaLinear Modelsarterial stiffnessendotheliumepidemiologyhyperemiavascular function

Identifiers

PMID27789476
PMCPMC5557404
OpenAlexW2542104159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.