ArticleClinical immunology (Orlando, Fla.)2016
A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model.
Article in Clinical immunology (Orlando, Fla.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Advances in Shellfish Allergy Therapy: From Current Approaches to Future Strategies.Clinical reviews in allergy & immunology · 2025Review
- Postbiotics: As a Promising Tools in the Treatment of Celiac Disease.Probiotics and antimicrobial proteins · 2025Review
- RNA-seq analysis of shrimp tropomyosin-induced allergic reactions through PI3K/Akt pathway.Frontiers in nutrition · 2025Article
- Impact of ovalbumin allergy on oral and gut microbiome dynamics in 6-week-old BALB/c mice.Frontiers in microbiology · 2024Article
- Gut microbiome features in pediatric food allergy: a scoping review.Frontiers in allergy · 2024Article
- Gut Microbiota and Fecal Microbiota Transplantation in Patients with Food Allergies: A Systematic Review.Microorganisms · 2022Article
- Assessment of the Route of Exposure to Ovalbumin and Cow's Milk Proteins on the Induction of IgE Responses in BALB/c Mice.Biology · 2022Article
- Suspected gut barrier disruptors and development of food allergy: Adjuvant effects and early immune responses.Frontiers in allergy · 2022Article
- Article
- Alteration of Intestinal Microbiota Composition in Oral Sensitized C3H/HeJ Mice Is Associated With Changes in Dendritic Cells and T Cells in Mesenteric Lymph Nodes.Frontiers in immunology · 2021Article
- Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice.Frontiers in immunology · 2021Article
- Methylglyoxal Decoration of Glutenin during Heat Processing Could Alleviate the Resulting Allergic Reaction in Mice.Nutrients · 2020Article
- Changes in Cold and Hot Syndrome and Gastrointestinal Bacterial Community Structure in Mice by Intervention with Food of Different Nature.Chinese journal of integrative medicine · 2020Article
- New Perspectives in Food Allergy.International journal of molecular sciences · 2020Review
- Review
- Dysbiosis of the gut and lung microbiome has a role in asthma.Seminars in immunopathology · 2020Review
- The gut microbiota, environmental factors, and links to the development of food allergy.Clinical and molecular allergy : CMA · 2020Review
- Relevant fecal microbes isolated from mice with food allergy elicited intestinal cytokine/chemokine network and T-cell immune responses.Bioscience of microbiota, food and health · 2020Article
- Country-wide medical records infer increased allergy risk of gastric acid inhibition.Nature communications · 2019Article
- AllergoOncology: Microbiota in allergy and cancer-A European Academy for Allergy and Clinical Immunology position paper.Allergy · 2019Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
Abstract
In our mouse model, gastric acid-suppression is associated with antigen-specific IgE and anaphylaxis development. We repeatedly observed non-responder animals protected from food allergy. Here, we aimed to analyse reasons for this protection. Ten out of 64 mice, subjected to oral ovalbumin (OVA) immunizations under gastric acid-suppression, were non-responders without OVA-specific IgE or IgG1 elevation, indicating protection from allergy. In these non-responders, allergen challenges confirmed reduced antigen uptake and lack of anaphylactic symptoms, while in allergic mice high levels of mouse mast-cell protease-1 and a body temperature reduction, indicative for anaphylaxis, were determined. Upon OVA stimulation, significantly lower IL-4, IL-5, IL-10 and IL-13 levels were detected in non-responders, while IL-22 was significantly higher. Comparison of fecal microbiota revealed differences of bacterial communities on single bacterial Operational-Taxonomic-Unit level between the groups, indicating protection from food allergy being associated with a distinct microbiota composition in a non-responding phenotype in this mouse model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.