Evidence map›Paper›PMID 27789200›Full record

ArticleObesity research & clinical practice

Maternal pre-pregnancy body mass index and circulating microRNAs in pregnancy.

Daniel A Enquobahrie, Pandora L Wander, Mahlet G Tadesse, Chunfang Qiu, Claudia Holzman, Michelle A Williams

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity research & clinical practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniel A EnquobahrieCenter for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Pandora L WanderDepartment of Medicine, University of Washington, Seattle, WA, USA. Electronic address: lwander@u.washington.edu.
Mahlet G TadesseDepartment of Mathematics and Statistics, Georgetown University, Washington DC, USA.
Chunfang QiuCenter for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA.
Claudia HolzmanDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
Michelle A WilliamsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Funding

Etiologic Heterogeneity in Preterm DeliveryR01HD034543 · NICHD · MICHIGAN STATE UNIVERSITY · PI HOLZMAN, CLAUDIA B. · 1997 to 2005
$5.3M
The Epidemiology of Marine Fatty Acids and PreeclampsiaR01HD032562 · NICHD · SWEDISH MEDICAL CENTER, FIRST HILL · PI WILLIAMS, MICHELLE A. · 1996 to 2006
$3.0M
Circulating MicroRNAs and HyperglycemiaK08DK103945 · NIDDK · UNIVERSITY OF WASHINGTON · PI JANUSZEWSKI, PANDORA LUKE · 2015 to 2019
$782k
Vitamin D related genes and developmental origins of cardiometabolic riskK01HL103174 · NHLBI · UNIVERSITY OF WASHINGTON · PI ENQUOBAHRIE, DANIEL ASMAMAW · 2010 to 2014
$661k
NHLBI NIH HHS K01 HL103174NICHD NIH HHS R01 HD032562NICHD NIH HHS R01 HD034543NIDDK NIH HHS K08 DK103945
6 · The paper itself

Abstract

backgroundMaternal pre-pregnancy overweight and obese status has been associated with a number of pregnancy complications and adverse offspring outcomes. Mechanisms for observed associations, however, are largely unknown. We investigated associations of pre-pregnancy body mass index with early-mid pregnancy epigenetic biomarkers, circulating microRNAs.

methodsPeripheral blood was collected from participants (16-27 weeks gestation) of two multi-racial pregnancy cohorts, the Omega Study and the Pregnancy Outcomes and Community Health Study. Plasma miRNA expression was characterised using epigenome-wide (319 miRNAs) profiling among 20 pregnant women in each cohort. Cohort-specific linear regression models that included the predictor (pre-pregnancy body mass index), the outcome (microRNA expression), and adjustment factors (maternal age, gestational age at blood collection, and race) were fit.

resultsExpression of 27 miRNAs was positively associated with pre-pregnancy body mass index in both cohorts (p-values <0.05). A number of these differentially expressed miRNAs have previously been associated with adipogenesis (e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b). Identified miRNAs as well as their experimentally validated targets participate in pathways that involve organismal injury, reproductive system disease, connective tissue disorders, cancer, cellular development, growth and proliferation.

conclusionPre-pregnancy body mass index is associated with circulating miRNAs in early-mid pregnancy.

Indexed as

Body Mass IndexAdipogenesisAdultCase-Control StudiesCirculating MicroRNACohort StudiesFemaleGestational AgeHumansMaternal AgeObesityOverweightPregnancySocioeconomic FactorsYoung AdultCirculating MicroRNAEpigeneticsMicroRNAsPregnancyPre-pregnancy obesity

Identifiers

PMID27789200
PMCPMC5403633

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.