ArticleUltrasound in medicine & biology2017
The Effects of Oxygen on Ultrasound-Induced Blood-Brain Barrier Disruption in Mice.
Article in Ultrasound in medicine & biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 57 citations in OpenAlex.
- Focused ultrasound-mediated opening of the blood brain barrier for non-invasive drug delivery to the murine cerebellum.Drug delivery and translational research · 2026Article
- Nitrous oxide enhances MR-guided focused ultrasound delivery of gene therapy to the murine hippocampus.Gene therapy · 2025Article
- Ultrasound-responsive nanoparticles for imaging and therapy of brain tumors.Materials today. Bio · 2025Review
- Innovative Approaches to Brain Cancer: The Use of Magnetic Resonance-guided Focused Ultrasound in Glioma Therapy.Cancers · 2024Review
- Article
- Controlled oxygen delivery to power tissue regeneration.Nature communications · 2024Review
- The new insight into the inflammatory response following focused ultrasound-mediated blood-brain barrier disruption.Fluids and barriers of the CNS · 2022Article
- Molecular Imaging of Ultrasound-Mediated Blood-Brain Barrier Disruption in a Mouse Orthotopic Glioblastoma Model.Pharmaceutics · 2022Article
- An Affordable and Easy-to-Use Focused Ultrasound Device for Noninvasive and High Precision Drug Delivery to the Mouse Brain.IEEE transactions on bio-medical engineering · 2022Article
- Ultrasound-Mediated Blood-Brain Barrier Disruption for Drug Delivery: A Systematic Review of Protocols, Efficacy, and Safety Outcomes from Preclinical and Clinical Studies.Pharmaceutics · 2022Review
- Profiling of the immune landscape in murine glioblastoma following blood brain/tumor barrier disruption with MR image-guided focused ultrasound.Journal of neuro-oncology · 2022Article
- Cavitation-modulated inflammatory response following focused ultrasound blood-brain barrier opening.Journal of controlled release : official journal of the Controlled Release Society · 2021Article
- Therapeutic Agent Delivery Across the Blood-Brain Barrier Using Focused Ultrasound.Annual review of biomedical engineering · 2021Review
- Characterization of ultrasound-mediated delivery of trastuzumab to normal and pathologic spinal cord tissue.Scientific reports · 2021Article
- Microbubble formulation influences inflammatory response to focused ultrasound exposure in the brain.Scientific reports · 2020Article
- Observed Effects of Whole-Brain Radiation Therapy on Focused Ultrasound Blood-Brain Barrier Disruption.Ultrasound in medicine & biology · 2020Article
- Enhanced Detection of Bubble Emissions Through the Intact Spine for Monitoring Ultrasound-Mediated Blood-Spinal Cord Barrier Opening.IEEE transactions on bio-medical engineering · 2020Article
- Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure.Theranostics · 2020Article
- Ultrafast three-dimensional microbubble imagingTheranostics · 2020Article
- Histologic evaluation of activation of acute inflammatory response in a mouse model following ultrasound-mediated blood-brain barrier using different acoustic pressures and microbubble doses.Nanotheranostics · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Numerous researchers are investigating the use of microbubble-enhanced ultrasound to disrupt the blood-brain barrier (BBB) and deliver drugs to the brain. This study investigated the impact of using oxygen as a carrier gas for anesthesia on microbubble activity and BBB disruption. Targets in mice were sonicated in combination with administration of Optison microbubbles (100 μL/kg) under isoflurane anesthesia with either oxygen or medical air. A 690-kHz focused ultrasound transducer applied 10-ms bursts at peak pressure amplitudes of 0.46-0.54 MPa (n = 2) or 0.34-0.36 MPa (n = 5). After sonication of two locations in one hemisphere, the carrier gas for the anesthesia was changed and the sonications were repeated in the contralateral hemisphere. The BBB disruption, measured via contrast-enhanced magnetic resonance imaging, was significantly greater (p < 0.001) with medical air than with oxygen. Harmonic emissions were also greater with air (p < 0.001), while the decay rate of the harmonic emissions was 1.5 times faster with oxygen. A good correlation (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.