ArticleThe Journal of pediatrics2017
Circulating Inflammatory-Associated Proteins in the First Month of Life and Cognitive Impairment at Age 10 Years in Children Born Extremely Preterm.
Article in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Association Between Newborn Thyroid-Stimulating-Hormone Concentration and Neurodevelopment and Growth: a Systematic Review.Biological trace element research · 2022Pooled it
- Intermittent hypoxia and caffeine in infants born preterm: the ICAF Randomized Clinical Trial.Archives of disease in childhood. Fetal and neonatal edition · 2026Trial
- Trial
- Trial
- Early predictors of cognitive trajectories from birth to adolescence in children born extremely preterm.Developmental medicine and child neurology · 2026Article
- Protein epigenetic scores derived in neonatal saliva as biomarkers of childhood cognition.Molecular psychiatry · 2026Article
- Protective versus Risk Factors for 18-month Outcomes in a multi-decade sample of preterm infants age 23-30 weeks.Medical research archives · 2025Article
- Incidence and outcomes of neonatal group B streptococcal sepsis in Qatar-a multicentre study.BMC pediatrics · 2025Article
- Serum cytokine profiles at near term-equivalent age and their association with neurodevelopmental outcomes in preterm infants: an exploratory study.Frontiers in pediatrics · 2025Article
- Chronic Inflammation Offers Hints About Viable Therapeutic Targets for Preeclampsia and Potentially Related Offspring Sequelae.International journal of molecular sciences · 2024Review
- Neonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm.Pediatric research · 2024Article
- DNA Methylation, Inflammation, and Neurobehavior in Preterm Infants.Biological research for nursing · 2024Article
- Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series).Pediatric research · 2024Review
- Review
- Accelerated Aging and the Life Course of Individuals Born Preterm.Children (Basel, Switzerland) · 2023Review
- Maternal vitamin D deficiency in early pregnancy and perinatal and long-term outcomes.Heliyon · 2023Article
- CpG methylation patterns in placenta and neonatal blood are differentially associated with neonatal inflammation.Pediatric research · 2023Article
- The use of multiple datasets to identify autophagy-related molecular mechanisms in intracerebral hemorrhage.Frontiers in genetics · 2023Article
- Cognitive changes mediated by adenosine receptor blockade in a resveratrol-treated atherosclerosis-prone lupus mouse model.Journal of traditional and complementary medicine · 2022Article
- Connexins, Pannexins and Gap Junctions in Perinatal Brain Injury.Biomedicines · 2022Review
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate whether in children born extremely preterm, indicators of sustained systemic inflammation in the first month of life are associated with cognitive impairment at school age. STUDY
designA total of 873 of 966 eligible children previously enrolled in the multicenter Extremely Low Gestational Age Newborn Study from 2002 to 2004 were evaluated at age 10 years. We analyzed the relationship between elevated blood concentrations of inflammation-associated proteins in the first 2 weeks ("early elevations"; n = 812) and the third and fourth week ("late elevations"; n = 532) of life with neurocognition.
resultsEarly elevations of C-reactive protein, tumor necrosis factor-α, interleukin (IL)-8, intercellular adhesion molecule (ICAM)-1, and erythropoietin were associated with IQ values >2 SD below the expected mean (ORs: 2.0-2.3) and with moderate to severe cognitive impairment on a composite measure of IQ and executive function (ORs: 2.1-3.6). Additionally, severe cognitive impairment was associated with late protein elevations of C-reactive protein (OR: 4.0; 95% CI 1.5, 10), IL-8 (OR: 5.0; 1.9, 13), ICAM-1 (OR: 6.5; 2.6, 16), vascular endothelial growth factor-receptor 2 (OR: 3.2; 1.2, 8.3), and thyroid-stimulating hormone (OR: 3.1; 1.3, 7.3). Moderate cognitive impairment was most strongly associated with elevations of IL-8, ICAM-1, and vascular endothelial growth factor-receptor 2. When 4 or more inflammatory proteins were elevated early, the risk of having an IQ <70 and having overall impaired cognitive ability was more than doubled (ORs: 2.1-2.4); the presence of 4 or more inflammatory protein elevated late was strongly linked to adverse cognitive outcomes (ORs: 2.9-4.8).
conclusionsExtremely preterm children who had sustained elevations of inflammation-related proteins in the first postnatal month are more likely than extremely preterm peers without such elevations to have cognitive impairment at 10 years.
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