ArticlePloS one2016
DNA Methylation Patterns in the Hypothalamus of Female Pubertal Goats.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Metabolomic and Transcriptomic Analyses Reveal the Potential Mechanisms of Dynamic Ovarian Development in Goats during Sexual Maturation.International journal of molecular sciences · 2024Article
- Grid1 regulates the onset of puberty in female rats.The Journal of veterinary medical science · 2024Article
- Photoperiod Induces DNA Methylation Changes in the Melatonin Receptor 1A Gene in Ewes.Animals : an open access journal from MDPI · 2023Article
- Genetics of pubertal delay.Clinical endocrinology · 2022Review
- Genome-Wide DNA Methylation Patterns of Muscle and Tail-Fat in DairyMeade Sheep and Mongolian Sheep.Animals : an open access journal from MDPI · 2022Article
- Effects of different energy diets on DNA methylation and mRNA expression in follicle stimulating hormone receptor gene promoter region of Duolang sheep during estrus.Molecular biology reports · 2022Article
- Integrated analyses of the methylome and transcriptome to unravel sex differences in the perirenal fat from suckling lambs.Frontiers in genetics · 2022Article
- Methylation status of hypothalamicFrontiers in endocrinology · 2022Article
- Integrative Genome-Wide DNA Methylome and Transcriptome Analysis of Ovaries from Hu Sheep with High and Low Prolific.Frontiers in cell and developmental biology · 2022Article
- Chicken cecal DNA methylome alteration in the response to Salmonella enterica serovar Enteritidis inoculation.BMC genomics · 2020Article
- Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Effect of GABA-T on Reproductive Function in Female Rats.Animals : an open access journal from MDPI · 2020Article
- Delayed Puberty-Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries.Endocrine reviews · 2019Review
- The Emerging Role of Chromatin Remodeling Factors in Female Pubertal Development.Neuroendocrinology · 2019Review
- The Genetic Basis of Delayed Puberty.Frontiers in endocrinology · 2019Review
- Genome-Wide DNA Methylation Analysis of Hypothalamus During the Onset of Puberty in Gilts.Frontiers in genetics · 2019Article
- Genome-wide DNA methylation analysis of pituitaries during the initiation of puberty in gilts.PloS one · 2019Article
- Hypothalamic epigenetics driving female puberty.Journal of neuroendocrinology · 2018Review
- Genome-wide differences in DNA methylation changes in caprine ovaries between oestrous and dioestrous phases.Journal of animal science and biotechnology · 2018Article
- Genome-Wide Analysis on the Landscape of Transcriptomes and Their Relationship With DNA Methylomes in the Hypothalamus Reveals Genes Related to Sexual Precocity in Jining Gray Goats.Frontiers in endocrinology · 2018Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Female pubertal development is tightly controlled by complex mechanisms, including neuroendocrine and epigenetic regulatory pathways. Specific gene expression patterns can be influenced by DNA methylation changes in the hypothalamus, which can in turn regulate timing of puberty onset. In order to understand the relationship between DNA methylation changes and gene expression patterns in the hypothalamus of pubertal goats, whole-genome bisulfite sequencing and RNA-sequencing analyses were carried out. There was a decline in DNA methylation levels in the hypothalamus during puberty and 268 differentially methylated regions (DMR) in the genome, with differential patterns in different gene regions. There were 1049 genes identified with distinct expression patterns. High levels of DNA methylation were detected in promoters, introns and 3'-untranslated regions (UTRs). Levels of methylation decreased gradually from promoters to 5'-UTRs and increased from 5'-UTRs to introns. Methylation density analysis demonstrated that methylation level variation was consistent with the density in the promoter, exon, intron, 5'-UTRs and 3'-UTRs. Analyses of CpG island (CGI) sites showed that the enriched gene contents were gene bodies, intergenic regions and introns, and these CGI sites were hypermethylated. Our study demonstrated that DNA methylation changes may influence gene expression profiles in the hypothalamus of goats during the onset of puberty, which may provide new insights into the mechanisms involved in pubertal onset.
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