ArticlePloS one2016
Image-Based Modeling of Blood Flow and Oxygen Transfer in Feto-Placental Capillaries.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Placental Blood-Flow Velocity Quantification From Diffusion MRI.Magnetic resonance in medicine · 2026Article
- Early Placental Angioactive Response to Maternal SARS-CoV-2 Infection: an Immunohistochemical Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- A functional shunt in the umbilical cord: the role of coiling in solute and heat transfer.Journal of the Royal Society, Interface · 2025Article
- A flexible generative algorithm for growing in silico placentas.PLoS computational biology · 2024Article
- A review of feto-placental vasculature flow modelling.Placenta · 2023Review
- Developments in functional imaging of the placenta.The British journal of radiology · 2023Review
- Feto-placental Unit: From Development to Function.Advances in experimental medicine and biology · 2023Review
- The role of the placenta in spontaneous preterm labor and delivery with intact membranes.Journal of perinatal medicine · 2022Observational
- Challenges and opportunities of integrating imaging and mathematical modelling to interrogate biological processes.The international journal of biochemistry & cell biology · 2022Review
- The Role of the 3Rs for Understanding and Modeling the Human Placenta.Journal of clinical medicine · 2021Review
- A massively multi-scale approach to characterizing tissue architecture by synchrotron micro-CT applied to the human placenta.Journal of the Royal Society, Interface · 2021Article
- Disorders of placental villous maturation are present in one-third of cases with spontaneous preterm labor.Journal of perinatal medicine · 2021Article
- Structure-function relationships in the feto-placental circulation from in silico interpretation of micro-CT vascular structures.Journal of theoretical biology · 2021Article
- Mathematical modelling of fluid flow and solute transport to define operating parameters forInterface focus · 2020Article
- Microphysiological systems of the placental barrier.Advanced drug delivery reviews · 2020Review
- Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networks.Interface focus · 2019Article
- Differences in placental capillary shear stress in fetal growth restriction may affect endothelial cell function and vascular network formation.Scientific reports · 2019Article
- Physical and geometric determinants of transport in fetoplacental microvascular networks.Science advances · 2019Article
- Blood flow and transport in the human placenta.Annual review of fluid mechanics · 2019Article
- Human placental oxygenation in late gestation: experimental and theoretical approaches.The Journal of physiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
During pregnancy, oxygen diffuses from maternal to fetal blood through villous trees in the placenta. In this paper, we simulate blood flow and oxygen transfer in feto-placental capillaries by converting three-dimensional representations of villous and capillary surfaces, reconstructed from confocal laser scanning microscopy, to finite-element meshes, and calculating values of vascular flow resistance and total oxygen transfer. The relationship between the total oxygen transfer rate and the pressure drop through the capillary is shown to be captured across a wide range of pressure drops by physical scaling laws and an upper bound on the oxygen transfer rate. A regression equation is introduced that can be used to estimate the oxygen transfer in a capillary using the vascular resistance. Two techniques for quantifying the effects of statistical variability, experimental uncertainty and pathological placental structure on the calculated properties are then introduced. First, scaling arguments are used to quantify the sensitivity of the model to uncertainties in the geometry and the parameters. Second, the effects of localized dilations in fetal capillaries are investigated using an idealized axisymmetric model, to quantify the possible effect of pathological placental structure on oxygen transfer. The model predicts how, for a fixed pressure drop through a capillary, oxygen transfer is maximized by an optimal width of the dilation. The results could explain the prevalence of fetal hypoxia in cases of delayed villous maturation, a pathology characterized by a lack of the vasculo-syncytial membranes often seen in conjunction with localized capillary dilations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.