ArticleJournal of the American Chemical Society2016
Enantioselective Aza-Sakurai Cyclizations: Dual Role of Thiourea as H-Bond Donor and Lewis Base.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The impact of supramolecular self-association of organocatalysts on catalytic performance.Nature reviews. Chemistry · 2025Review
- AnOrganic letters · 2023Article
- Development of a Non-Directed Petasis-Type Reaction by an Aromaticity-Disrupting Strategy.Angewandte Chemie (International ed. in English) · 2023Article
- Mechanism of a Dually Catalyzed Enantioselective Oxa-Pictet-Spengler Reaction and the Development of a Stereodivergent Variant.ACS catalysis · 2023Article
- Transition-metal free C-N bond formation from alkyl iodides and diazonium salts via halogen-atom transfer.Nature communications · 2022Article
- Halides as versatile anions in asymmetric anion-binding organocatalysis.Beilstein journal of organic chemistry · 2021Review
- Synthesis of Novel 2-(Het)arylpyrrolidine Derivatives and Evaluation of Their Anticancer and Anti-Biofilm Activity.Molecules (Basel, Switzerland) · 2019Article
- Enantioselective Synthesis of α-Allyl Amino Esters via Hydrogen-Bond-Donor Catalysis.Journal of the American Chemical Society · 2019Article
- Synthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling.Journal of the American Chemical Society · 2018Article
- Chiral Thioureas Promote Enantioselective Pictet-Spengler Cyclization by Stabilizing Every Intermediate and Transition State in the Carboxylic Acid-Catalyzed Reaction.Journal of the American Chemical Society · 2017Article
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Authors and funding
3 authors.
Funding
Abstract
An enantioselective, catalytic aza-Sakurai cyclization of chlorolactams has been developed as an efficient entry into indolizidine and quinolizidine frameworks. Structure-enantioselectivity relationship studies and mechanistic analysis point to a dual role of the catalyst wherein the thiourea moiety of the catalyst is engaged in both anion binding and Lewis base activation of a substrate.
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