Evidence map›Paper›PMID 27787895›Full record

Trial reportJournal of the American Geriatrics Society2016

Regional Nerve Blocks Improve Pain and Functional Outcomes in Hip Fracture: A Randomized Controlled Trial.

R Sean Morrison, Eitan Dickman, Ula Hwang, Saadia Akhtar, Taja Ferguson, Jennifer Huang, Christina L Jeng, Bret P Nelson, Meg A Rosenblatt, Jeffrey H Silverstein and 3 more

6 registry-linked trialsAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 73 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 7 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03092466 naunknown statusnot on this mapstarted 2017, after this paper: background citation

A Prospective, Randomized, Double-blind, Multicenter Trial on the Effects of the Early Femoral Nerve Block in Elderly With Hip Fracture

TypeinterventionalSponsorASST Gaetano Pini-CTORan2017 to 2024Enrolled600ConditionsHip FracturesArmsfemoral nerve catheter, femoral group, control group
NCT03289858 phase4completednot on this mapstarted 2017, after this paper: background citation

Does the Use of Liposomal Bupivacaine Decrease Narcotic Requirements in Geriatric Hip Fractures? A Randomized, Double Blinded Control Trial

TypeinterventionalSponsorUniversity of Massachusetts, WorcesterRan2017 to 2019Enrolled55ConditionsHip FracturesArmsExparel, Sodium Chloride
NCT03846102 phase4terminatednot on this mapstarted 2019, after this paper: background citation

MORphine Use in the Fascia Iliaca Compartment Block With UltraSound

TypeinterventionalSponsorZuyderland Medisch CentrumRan2019 to 2020Enrolled55ConditionsHumans, Anesthetics, Local, Morphine, Pain ManagementArmsLevobupivacaine, Placebo, Acetaminophen, Morphine, Fascia Iliaca Compartment Block with Levobupivacaine
NCT04335461 early_phase1withdrawnnot on this mapstarted 2021, after this paper: background citation

Postoperative Pain Control in Extracapsular Hip Fracture Patients: Fascia Iliaca Compartment Block Versus Fracture Block

TypeinterventionalSponsorMontefiore Medical CenterRan2021 to 2023Enrolled0ConditionsHip Fractures, Analgesia, Opioid Use, Pain, PostoperativeArmsCephalomedullary nailing of extracapsular hip fracture, cephalomedullary nail, Regional Anesthetics
NCT04564326 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Pericapsular Nerve Group Block Versus Fascia Iliaca Block for Pre- and Post-Operative Analgesia in Elderly Patients With Hip Fracture

TypeinterventionalSponsorZagazig UniversityRan2021 to 2022Enrolled51ConditionsHip FracturesArmsPericapsular nerve Group block, Facia Iliaca block, Fentanyl
NCT04882384 nacompletednot on this mapstarted 2021, after this paper: background citation

Pericapsular Nerve Group Blocks for Hip Fractures in the Emergency Department: A Prospective, Observational, Feasibility Study

TypeinterventionalSponsorJacobi Medical CenterRan2021 to 2022Enrolled10ConditionsHip Fractures, Pain, AcuteArmsPericapsular Nerve Group Block
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 7 syntheses or guidelines pooled it, 155 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Peripheral nerve blocks for hip fractures in adults.The Cochrane database of systematic reviews · 2020
    Pooled it
  7. Guideline
  8. Trial
  9. Trial
  10. Race, ethnicity, and language are underreported in hip fracture CPGs.Archives of orthopaedic and trauma surgery · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. A Novel Low-Cost Phantom for Ultrasound-Guided Fascia Iliaca Nerve Blocks.Journal of education & teaching in emergency medicine · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

R Sean MorrisonDepartment of Anesthesia, Icahn School of Medicine at Mount Sinai, New York City, New York.
Eitan DickmanMaimonides Medical Center, Brooklyn, New York.
Ula HwangDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Saadia AkhtarMount Sinai Beth Israel, New York City, New York.
Taja FergusonDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Jennifer HuangDepartment of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Christina L JengDepartment of Anesthesia, Icahn School of Medicine at Mount Sinai, New York City, New York.
Bret P NelsonDepartment of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Meg A RosenblattDepartment of Anesthesia, Icahn School of Medicine at Mount Sinai, New York City, New York.
Jeffrey H SilversteinDepartment of Anesthesia, Icahn School of Medicine at Mount Sinai, New York City, New York.
Reuben J StrayerDepartment of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Toni M TorrilloDepartment of Anesthesia, Icahn School of Medicine at Mount Sinai, New York City, New York.
Knox H ToddMount Sinai Beth Israel, New York City, New York.
Icahn School of Medicine at Mount Sinai · USMaimonides Medical Center · USMount Sinai Beth Israel · USThe University of Texas MD Anderson Cancer Center · US

Funding

Residing in the Community with Dementia at the End of Life: Understanding Hospice Use and Residential SettingP30AG028741 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI R. Sean Morrison · 2010 to 2026
$21.9M
Improving pain and function in hip fractureR01AG030141 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORRISON, R. SEAN · 2008 to 2013
$3.8M
Pain Management and Functional Recovery in Older AdultsR01AG022108 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI MORRISON, R. SEAN · 2003 to 2006
$1.7M
Patient Oriented Research in Palliative Care and AgingK24AG022345 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI MORRISON, R. SEAN · 2003 to 2012
$1.5M
Geriatric Pain Care in the Emergency DepartmentK23AG031218 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HWANG, ULA Y · 2008 to 2012
$646k
NIA NIH HHS K23 AG031218NIA NIH HHS K24 AG022345NIA NIH HHS P30 AG028741NIA NIH HHS R01 AG022108NIA NIH HHS R01 AG030141
6 · The paper itself

Abstract

objectivesTo compared outcomes of regional nerve blocks with those of standard analgesics after hip fracture.

designMultisite randomized controlled trial from April 2009 to March 2013.

settingThree New York hospitals.

participantsIndividuals with hip fracture (N = 161).

interventionParticipants were randomized to receive an ultrasound-guided, single-injection, femoral nerve block administered by emergency physicians at emergency department (ED) admission followed by placement of a continuous fascia iliaca block by anesthesiologists within 24 hours (n = 79) or conventional analgesics (n = 82). MEASUREMENTS: Pain (0-10 scale), distance walked on Postoperative Day (POD) 3, walking ability 6 weeks after discharge, opioid side effects.

resultsPain scores 2 hours after ED presentation favored the intervention group over controls (3.5 vs 5.3, P = .002). Pain scores on POD 3 were significantly better for the intervention than the control group for pain at rest (2.9 vs 3.8, P = .005), with transfers out of bed (4.7 vs 5.9, P = .005), and with walking (4.1 vs 4.8, P = .002). Intervention participants walked significantly further than controls in 2 minutes on POD 3 (170.6 feet, 95% confidence interval (CI) = 109.3-232 vs 100.0 feet, 95% CI = 65.1-134.9; P = .04). At 6 weeks, intervention participants reported better walking and stair climbing ability (mean Functional Independence Measure locomotion score of 10.3 (95% CI = 9.6-11.0) vs 9.1 (95% CI = 8.2-10.0), P = .04). Intervention participants were significantly less likely to report opioid side effects (3% vs 12.4%, P = .03) and required 33% to 40% fewer parenteral morphine sulfate equivalents.

conclusionFemoral nerve blocks performed by emergency physicians followed by continuous fascia iliaca blocks placed by anesthesiologists are feasible and result in superior outcomes.

Indexed as

AgedAged, 80 and overFemaleFemoral NerveHip FracturesHumansMaleMiddle AgedNerve BlockNew YorkPain ManagementPain MeasurementPostoperative PainRecovery of FunctionTreatment OutcomeUltrasonography, Interventionalfunctional recoveryhip fracturepain

Identifiers

PMID27787895
PMCPMC5173407
OpenAlexW2542303190

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.