ArticleCancer2017
Family caregivers' level of mastery predicts survival of patients with glioblastoma: A preliminary report.
Article in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Depression and glioblastoma, complicated concomitant diseases: a systemic review of published literature.Neurosurgical review · 2020Pooled it
- Creating harmony at home via environmental cueing: A feasibility trial of a non-pharmacological intervention for rural caregivers of persons with dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- A randomized controlled trial of a distress screening, consultation, and targeted referral system for family caregivers in oncologic care.Psycho-oncology · 2024Trial
- The effects of SmartCareSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Trial
- Feasibility Testing and Refinement of a Supportive Educational Intervention for Carers of Patients with High-Grade Glioma - a Pilot Study.Journal of cancer education : the official journal of the American Association for Cancer Education · 2018Trial
- The Added Value of Family Caregivers' Level of Mastery in Predicting Survival of Glioblastoma Patients: A Validation Study.Cancer nursingTrial
- Associations between caregiver mastery and anxiety in persons living with dementia: A study of dyads living in community.Geriatric nursing (New York, N.Y.)Trial
- Understanding the unmet needs of patients with brain metastases referred for stereotactic radiotherapy and their caregivers: A prospective cohort study.Neuro-oncology practice · 2026Article
- A Scoping Review of Exercise Oncology in the Primary Brain Tumor Patient-Caregiver Dyad.Current oncology (Toronto, Ont.) · 2026Article
- Meaning-Centered Psychotherapy for Cancer Caregivers: Study protocol of a randomized controlled trial.Trials · 2026Article
- Associations of Cancer-Related Posttraumatic Stress Symptoms and Gender With Health Behaviors Among Caregivers of Adult Patients With Colorectal Cancer.Psycho-oncology · 2026Article
- Meaning-Centered Psychotherapy for Cancer Caregivers Study protocol of a randomized controlled trial.Research square · 2026Article
- Group-based interventions for caregivers to patients diagnosed with a brain tumor: A systematic review.Neuro-oncology practice · 2025Article
- Response Assessment in Neuro-Oncology (RANO) 2009-2025: Broad scope and implementation-A progress report.Neuro-oncology · 2025Review
- The communication of a high-grade glioma diagnosis- patients' reflections and perspectives based on a study-specific questionnaire.Journal of neuro-oncology · 2025Article
- A pilot study to quantify and describe personal social networks in patients with glioblastoma.Neuro-oncology practice · 2025Article
- Former Primary Caregivers of Patients With Glioblastoma Multiforme Evaluate the PATH (Preparedness Assessment for the Transition Home) Instrument.Journal of advanced nursing · 2025Article
- "You sure feel like you're alone, kind of flailing away out there": Family caregiver perspectives of caring for an individual with glioblastoma multiforme.Palliative & supportive care · 2025Article
- Reporting standards in randomized controlled trials involving neuro-oncology caregivers: A systematic review report from the RANO-Cares working group.Neuro-oncology practice · 2025Article
- Symptom management in isocitrate dehydrogenase mutant glioma.Neuro-oncology practice · 2025Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGlioblastoma multiforme (GBM) is associated with a poor prognosis, and patients rely heavily on family caregivers for physical and emotional support. The capability and mental health of family caregivers may influence their ability to provide care and affect patient outcomes. The objective of the current study was to investigate whether caregivers' anxiety, depressive symptoms, burden, and mastery influenced survival in a sample of patients newly diagnosed with GBM.
methodsBaseline data from caregiver-patient dyads participating in a longitudinal study funded by the National Institutes of Health were used. Cox regression analyses were performed to determine whether caregiver anxiety (Profile of Mood States-Anxiety), depressive symptoms (Center for Epidemiologic Studies-Depression Scale), burden (Caregiver Reaction Assessment), and feelings of mastery (Mastery Scale) predicted the survival time of patients with GBM after controlling for known covariates (patient age, Karnofsky performance status, type of surgery, and postsurgical treatment).
resultsA total of 88 caregiver-patient dyads were included. The median overall survival for the sample was 14.5 months (range, 0-88 months). After controlling for covariates, caregiver mastery was found to be predictive of patient survival. With each unit increase in mastery, there was a 16.1% risk reduction in patient death (95% confidence interval, 0.771-0.913; P<.001).
conclusionsTo the authors' knowledge, the results of the current study are among the first to explore the impact of family caregiving on the outcomes of patients with GBM. If these results are supported in other studies, providing neuro-oncology caregivers with more structured support and guidance in clinical practice has the potential to improve caregivers' feelings of mastery, thereby influencing patients' well-being for the better. Cancer 2017;123:832-40. © 2016 American Cancer Society.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.