Evidence map›Paper›PMID 27787863›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2017

Characterization of Semaphorin 6A-Mediated Effects on Angiogenesis Through Regulation of VEGF Signaling.

Hidetaka Ohnuki, Giovanna Tosato

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Semaphorins and Their Role in Neuropathic Pain.Life (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hidetaka OhnukiLaboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Building 37, Room 4124, 37 Convent Drive, Bethesda, MD, 20892, USA. hidetaka.ohnuki@nih.gov.
Giovanna TosatoLaboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Building 37, Room 4124, 37 Convent Drive, Bethesda, MD, 20892, USA.

Funding

Angiogenesis and Tumor GrowthZIASC010355 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI TOSATO, GIOVANNA · 2009 to 2025
$13.3M
Study of the Roles of SDF1 and CXCR4 in HematopoiesisZIABC010782 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TOSATO, GIOVANNA · 2009 to 2025
$10.2M
Angiogenesis and Tumor GrowthZ01SC010355 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI TOSATO, GIOVANNA · 2000 to 2008
$1.6M
Intramural NIH HHS Z01 SC010355
6 · The paper itself

Abstract

Angiogenesis identifies the process of endothelial cell sprouting and remodeling leading to the formation of new and functional blood vessels. Vascular expansion during development and in the adult mammal provides nutrients and oxygen to areas with increased need. Although many molecules and pathways have been identified as regulators of angiogenesis, aspects of this complex process remain unclear. Particularly undefined are the signals that orchestrate vessel survival and pruning once new blood vessels have sprouted. These poorly characterized aspects of angiogenesis need exploration. This chapter describes the experiments and methods enabling the characterization of Semaphorin 6A as a critical regulator of endothelial cell survival and vessel function.

Indexed as

Signal TransductionCell SurvivalEndothelium, VascularHumansHuman Umbilical Vein Endothelial CellsNeovascularization, PhysiologicSemaphorinsVascular Endothelial Growth Factor ASemaphorinsVascular Endothelial Growth Factor AAngiogenesisbFGFCell deathCleaved caspase-3Endothelial cellsSemaphorinVasculatureVEGFVEGFR

Identifiers

PMID27787863
PMCPMC6348469

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.