ReviewCurrent hypertension reports2016
A Clinical Perspective: Contribution of Dysfunctional Perivascular Adipose Tissue (PVAT) to Cardiovascular Risk.
Review in Current hypertension reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Sodium-Glucose Cotransporter Protein 2 Inhibitors: Novel Application for the Treatment of Obesity-Associated Hypertension.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Angiotensin II Inhibits Adipogenic Differentiation and Promotes Mature Adipocyte Browning through the Corepressor CtBP1.Biomedicines · 2022Article
- DNA methylation profile of genes involved in inflammation and autoimmunity correlates with vascular function in morbidly obese adults.Epigenetics · 2022Article
- Adipose Tissue Hypoxia Correlates with Adipokine Hypomethylation and Vascular Dysfunction.Biomedicines · 2021Article
- Mineralocorticoid Receptor in Myeloid Cells Mediates Angiotensin II-Induced Vascular Dysfunction in Female Mice.Frontiers in physiology · 2021Article
- Hydrogen sulfide and vascular regulation - An update.Journal of advanced research · 2021Review
- Intrinsic Exercise Capacity and Mitochondrial DNA Lead to Opposing Vascular-Associated Risks.Function (Oxford, England) · 2021Article
- PVAT: an important guardian of the cardiovascular system.Histology and histopathology · 2020Review
- Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- HIF1α/TET1 Pathway Mediates Hypoxia-Induced Adipocytokine Promoter Hypomethylation in Human Adipocytes.Cells · 2020Article
- Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasome/IL-1 signaling pathway.Acta pharmacologica Sinica · 2019Article
- Perivascular Adipose Tissue-Enhanced Vasodilation in Metabolic Syndrome Rats by Apelin andInternational journal of molecular sciences · 2018Article
- Adipogenic potential of perivascular adipose tissue preadipocytes is improved by coculture with primary adipocytes.Cytotechnology · 2018Article
- Perivascular Adipose Tissue: the Sixth Man of the Cardiovascular System.Cardiovascular drugs and therapy · 2018Review
- Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension.Current hypertension reports · 2018Review
- RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in MiceFrontiers in physiology · 2018Article
- The Kv7 Channel and Cardiovascular Risk Factors.Frontiers in cardiovascular medicine · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perivascular adipose tissue (PVAT) is now recognized as an important paracrine organ influencing the homeostasis of the vessel wall, regional blood flow and peripheral arterial resistance. There is remarkable phenotypic variability and plasticity of PVAT among various vascular beds, exhibiting phenotypes from white to brown and beige adipocytes. PVAT dysfunction is characterized by disturbed secretion of various adipokines, which, together with endothelial dysfunction, contribute to hypertension and cardiovascular disease (CVD). This brief review describes our current knowledge on PVAT in health and cardiovascular disease, with a special focus on different phenotypes and signaling pathways in adipocytes of PVAT associated with hypertension, obesity and cardiovascular disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.