Evidence map›Paper›PMID 27787773›Full record

ArticleEating and weight disorders : EWD2018

Bone metabolism in patients with anorexia nervosa and amenorrhoea.

L Idolazzi, M El Ghoch, R Dalle Grave, P V Bazzani, S Calugi, S Fassio, C Caimmi, O Viapiana, F Bertoldo, V Braga and 2 more

Erratum issuedOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Eating and weight disorders : EWD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Review
  10. Anorexia Nervosa and Bone.Current opinion in endocrine and metabolic research · 2018
    Article
  11. Article
  12. Eating disorders and bone metabolism in women.Current opinion in pediatrics · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

L IdolazziUnit of Rheumatology, University of Verona, P.le L. Scuro 2, 37134, Verona, Italy. luca.idolazzi@univr.it.
M El GhochDepartment of Eating and Weight Disorders, Villa Garda Hospital, Via Montebaldo, 89, Garda, 37016, Verona, Italy.
R Dalle GraveDepartment of Eating and Weight Disorders, Villa Garda Hospital, Via Montebaldo, 89, Garda, 37016, Verona, Italy.
P V BazzaniDepartment of Eating and Weight Disorders, Villa Garda Hospital, Via Montebaldo, 89, Garda, 37016, Verona, Italy.
S CalugiDepartment of Eating and Weight Disorders, Villa Garda Hospital, Via Montebaldo, 89, Garda, 37016, Verona, Italy.
S FassioUnit of Rheumatology, University of Verona, P.le L. Scuro 2, 37134, Verona, Italy.
C CaimmiUnit of Rheumatology, University of Verona, P.le L. Scuro 2, 37134, Verona, Italy.
O ViapianaUnit of Rheumatology, University of Verona, P.le L. Scuro 2, 37134, Verona, Italy.
F BertoldoInternal Medicine, University of Verona, P.le L. Scuro 2, 37134, Verona, Italy.
V BragaUnit of Rheumatology, University of Verona, P.le L. Scuro 2, 37134, Verona, Italy.
M RossiniUnit of Rheumatology, University of Verona, P.le L. Scuro 2, 37134, Verona, Italy.
D GattiUnit of Rheumatology, University of Verona, P.le L. Scuro 2, 37134, Verona, Italy.
University of Verona · ITCasa di Cura Villa Garda · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAim of this study is focusing on bone metabolism in AN patients with amenorrhoea and related estrogen deficiency effects.

methodsAN patients were compared both with healthy females and with postmenopausal women (reference model for estrogen deficiency). The study sample included 81 females with AN. Laboratory tests [25-OH vitamin D, bone turnover markers, intact parathyroid hormone, sclerostin (SOST) and dickkopf-related protein (DKK1)] and dual energy X-ray absorptiometry (DXA) were taken into account.

resultsAN patients had higher levels of C-terminal telopeptide of type I collagen (CTX) than both control groups. AN adolescents had CTX higher than AN young adults. In postmenopausal women, intact N-propeptide of type I collagen was higher if compared with each other group. In AN groups, Dickkopf-related protein 1 was significantly lower than the two control groups. No differences were found in sclerostin except in adolescents. In AN adolescents, DXA values at femoral sites were higher than in AN young adults and a positive correlation was found with body weight (p < 0.01) and with fat mass evaluated using DXA (p < 0.01).

conclusionsAN women with amenorrhoea have an increased bone resorption like postmenopausal women but bone formation is depressed. The consequent remodeling uncoupling is considerably more severe than that occurring after menopause.

Indexed as

AdolescentAdultAmenorrheaAnorexia NervosaBiomarkersBody CompositionBody WeightBone and BonesBone DensityCollagen Type IFemaleHumansParathyroid HormonePhosphopeptidesProcollagenVitamin D25-hydroxyvitamin DBiomarkersCollagen Type IN-propeptide type I collagenParathyroid HormonePhosphopeptidesProcollagenVitamin DAnorexia nervosaBody compositionBone turnover markersDKK-1Sclerostin

Identifiers

PMID27787773
OpenAlexW2400914596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.