Evidence map›Paper›PMID 27787743›Full record

ArticleJournal of bioenergetics and biomembranes2016

Respiratory chain inhibition: one more feature to propose MPTP intoxication as a Leigh syndrome model.

Barbara Da Costa, Elodie Dumon, Laurence Le Moigno, Sylvie Bodard, Pierre Castelnau, Thierry Letellier, Christophe Rocher

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of bioenergetics and biomembranes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Disease models of Leigh syndrome: From yeast to organoids.Journal of inherited metabolic disease · 2024
    Review
  2. Leigh Syndrome: A Tale of Two Genomes.Frontiers in physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Barbara Da CostaMétabolisme Energétique Cellulaire, Institut de Biochimie et Génétique Cellulaires, UMR 5095 CNRS/Univ. de Bordeaux, 1 Rue Camille Saint Saëns, CS 61390, F- 33000, Bordeaux, Cedex, France.
Elodie DumonMétabolisme Energétique Cellulaire, Institut de Biochimie et Génétique Cellulaires, UMR 5095 CNRS/Univ. de Bordeaux, 1 Rue Camille Saint Saëns, CS 61390, F- 33000, Bordeaux, Cedex, France.
Laurence Le MoignoUMR INSERM U 930, CNRS FRE 2448, François-Rabelais University, Child Neurology Unit, University Hospital, Tours, France.
Sylvie BodardUMR INSERM U 930, CNRS FRE 2448, François-Rabelais University, Child Neurology Unit, University Hospital, Tours, France.
Pierre CastelnauUMR INSERM U 930, CNRS FRE 2448, François-Rabelais University, Child Neurology Unit, University Hospital, Tours, France.
Thierry LetellierEquipe de Médecine Evolutive, AMIS, UMR 5288 CNRS/Univ. Paul Sabatier, F-31073, Toulouse, France.
Christophe RocherMétabolisme Energétique Cellulaire, Institut de Biochimie et Génétique Cellulaires, UMR 5095 CNRS/Univ. de Bordeaux, 1 Rue Camille Saint Saëns, CS 61390, F- 33000, Bordeaux, Cedex, France. christophe.rocher@u-bordeaux.fr.
AMIS - Laboratoire d'anthropologie moléculaire et imagerie de synthèse · FRInserm · FRUniversité Toulouse III - Paul Sabatier · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxicated mice have been widely used to model the loss of dopaminergic neurons. As this treatment leads to basal ganglia degeneration, it was proposed that MPTP mice could be used as a model of Leigh syndrome. However, this mitochondrial pathology is biochemically characterized by a respiratory chain dysfunction. To determine if MPTP can affect in vivo mitochondria function, we measured the activities of mitochondrial respiratory chain complexes in several tissues. Our results show that MPTP affects mainly mitochondrial respiratory chain complex IV, as found in Leigh Syndrome, confirming that acute MPTP intoxicated mice are a good model of Leigh Syndrome.

Indexed as

Disease Models, Animal1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsElectron TransportElectron Transport Complex IVLeigh DiseaseMiceMitochondriaMPTP Poisoning1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineElectron Transport Complex IVMice modelMitochondrial diseasesMPTPRespiratory chain

Identifiers

PMID27787743
OpenAlexW2541103269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.