Evidence map›Paper›PMID 27787699›Full record

ArticleThe international journal of cardiovascular imaging2017

The interplay between renin-angiotensin system activation, abnormal myocardial deformation and neurohumoral activation in hypertensive heart disease: a speckle tracking echocardiography study.

Ignatios Ikonomidis, Stavros Tzortzis, Argirios Tsantes, Konstantina Ntai, Helen Triantafyllidi, Paraskevi Trivilou, George Katsimaglis, Kleanthi Dima, John Parissis, John Lekakis

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03878706 (The Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination on Endothelial Function, Arterial Stiffness and Left Ventricular Deformation in Patients With Type 2 Diabetes With High Cardiovascular Risk), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03878706 recruitingnot on this map

The Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination on Endothelial Function, Arterial Stiffness and Left Ventricular Deformation in Patients With Type 2 Diabetes With High Cardiovascular Risk

Typeobservational_patient_registrySponsorUniversity of AthensRan2017 to 2027Enrolled240ConditionsDiabetes Mellitus, Type 2
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ignatios Ikonomidis2nd Cardiology Department, Attikon Hospital, University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece. ignoik@otenet.gr.
Stavros Tzortzis2nd Cardiology Department, Attikon Hospital, University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece.
Argirios Tsantes2nd Cardiology Department, Attikon Hospital, University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece.
Konstantina Ntai2nd Cardiology Department, Attikon Hospital, University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece.
Helen Triantafyllidi2nd Cardiology Department, Attikon Hospital, University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece.
Paraskevi Trivilou2nd Cardiology Department, Attikon Hospital, University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece.
George Katsimaglis2nd Cardiology Department, Attikon Hospital, University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece.
Kleanthi Dima2nd Cardiology Department, Attikon Hospital, University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece.
John Parissis2nd Cardiology Department, Attikon Hospital, University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece.
John Lekakis2nd Cardiology Department, Attikon Hospital, University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece.
National and Kapodistrian University of Athens · GRUniversity General Hospital Attikon · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiotensin converting enzyme (ACE) promotes cardiac fibrosis. LV myocardial deformation and torsion are markers of subclinical myocardial dysfunction. We investigated the association of serum ACE levels with LV deformation markers in untreated hypertensives. In 120 untreated patients (age: 53.5 ± 11.2 years) with essential hypertension and 60 healthy controls, we measured (a) LV longitudinal, circumferential and radial strain (S), peak torsion and the percentage changes between peak twisting and untwisting at the end of early diastolic filling (%dpTw-Utw

Indexed as

Myocardial ContractionRenin-Angiotensin SystemVentricular Function, LeftAdultAgedBiomarkersBiomechanical PhenomenaChi-Square DistributionEchocardiography, DopplerFemaleFibrosisHumansHypertensionLinear ModelsMaleMiddle AgedACE protein, humanBiomarkersNatriuretic Peptide, BrainPeptide FragmentsPeptidyl-Dipeptidase Apro-brain natriuretic peptide (1-76)FibrosisLV deformationSerum ACE levels

Identifiers

PMID27787699
OpenAlexW2542292930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.