Evidence map›Paper›PMID 27787576›Full record

ReviewDer Nervenarzt2016

[Gut microbiome and major depressive disorder : The other side of ourselves].

A Manook, A Hiergeist, R Rupprecht, T C Baghai

Abstract readReview
PubMed Publisher
In one paragraph

Review in Der Nervenarzt, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A ManookKlinik und Poliklinik für Psychiatrie und Psychotherapie, Universität Regensburg, Universitätsstraße 84, 93053, Regensburg, Deutschland.
A HiergeistInstitut für Klinische Mikrobiologie und Hygiene, Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
R RupprechtKlinik und Poliklinik für Psychiatrie und Psychotherapie, Universität Regensburg, Universitätsstraße 84, 93053, Regensburg, Deutschland.
T C BaghaiKlinik und Poliklinik für Psychiatrie und Psychotherapie, Universität Regensburg, Universitätsstraße 84, 93053, Regensburg, Deutschland. thomas.baghai@medbo.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbiological ecology and its ambition to describe the complete genome of complex living communities as a whole, have given us powerful tools to characterize the human gut microbiome on a genetic and, hence, taxonomic and abundance level; for a decade now, they have become sufficiently inexpensive, fast and feasible. Thus, opportunities arose to have a fresh and closer look at the microbiota-gut-brain-axis and its impact on human health; this axis comprises a complex multisystemic network of multidirectional interactions between brain and gut including influences beyond one generation. Gnotobiotic animal models have become essential for specific research targets. Combining gut microbiome analysis with observations on the hypothalamus-pituitary-adrenal axis and various aspects of inflammation helped to gain first insights into the role of the microbiota-gut-brain-axis in depressive disorders. Therapeutic endeavors with psychobiotics have not yet shown their value in clinical studies.

Indexed as

Gastrointestinal MicrobiomeHumansHypothalamo-Hypophyseal SystemMajor Depressive DisorderModels, BiologicalPituitary-Adrenal SystemFunctional imagingHypothalamo-hypophyseal systemMicrobiota-gut-brain-axisPsychobioticsTranslational metagenomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.