ArticleJournal of biomedical optics2016
Design and evaluation of a miniature laser speckle imaging device to assess gingival health.
Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Quantitative analysis of gingival vascular morphology using optical coherence tomography angiography in induced gingivitis.Biomedical optics express · 2025Article
- Multi-spectral laser speckle contrast imaging for depth-resolved blood perfusion assessment.Journal of biomedical optics · 2025Article
- Assessment of the efficiency of dental excavation methods using laser speckle imaging.Lasers in medical science · 2024Article
- Article
- Evaluation of perfusion parameters of gingival inflammation using laser Doppler flowmetry and tissue spectrophotometry- a prospective comparative clinical study.BMC oral health · 2023Article
- Comprehensive review of surgical microscopes: technology development and medical applications.Journal of biomedical optics · 2021Review
- Clinical applications of laser speckle contrast imaging: a review.Journal of biomedical optics · 2019Review
- Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance.Biomedical optics express · 2018Article
- Acute effects of traditional and electronic cigarettes on palatal blood flow in smokers: A cross-over pilot study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Current methods used to assess gingivitis are qualitative and subjective. We hypothesized that gingival perfusion measurements could provide a quantitative metric of disease severity. We constructed a compact laser speckle imaging (LSI) system that could be mounted in custom-made oral molds. Rigid fixation of the LSI system in the oral cavity enabled measurement of blood flow in the gingiva. In vitro validation performed in controlled flow phantoms demonstrated that the compact LSI system had comparable accuracy and linearity compared to a conventional bench-top LSI setup. In vivo validation demonstrated that the compact LSI system was capable of measuring expected blood flow dynamics during a standard postocclusive reactive hyperemia and that the compact LSI system could be used to measure gingival blood flow repeatedly without significant variation in measured blood flow values (p<0.05). Finally, compact LSI system measurements were collected from the interdental papilla of nine subjects and compared to a clinical assessment of gingival bleeding on probing. A statistically significant correlation (?=0.53; p<0.005) was found between these variables, indicating that quantitative gingival perfusion measurements performed using our system may aid in the diagnosis and prognosis of periodontal disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.