Observational studyMedicine2016
What ocular and systemic variables affect choroidal circulation in healthy eyes.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- A randomized clinical trial evaluating choroidal blood flow and morphology after conventional and pattern scan laser panretinal photocoagulation.Scientific reports · 2018Trial
- Choroidal Thickening and Reduced Macular Blood Flow in Children with Hyperopic Anisometropic Amblyopia.Journal of clinical medicine · 2026Article
- Intraoperative Ocular Blood Flow Dynamics in Response to Intraocular Pressure Fluctuations During Vitrectomy for Proliferative Diabetic Retinopathy.Journal of clinical medicine · 2026Article
- Effect of disease duration on foveal microvasculature assessed by OCTA in type 2 diabetes mellitus without clinical diabetic retinopathy.International journal of retina and vitreous · 2025Article
- Laser Speckle Flowgraphy Reveals Widespread Reductions in Ocular Blood Flow in nonexudative Age-Related Macular Degeneration.American journal of ophthalmology · 2025Article
- Influence of Aflibercept on Choroidal Blood Flow and Thickness in Branch Retinal Vein Occlusion: A Six-Month Follow-Up Study.Diagnostics (Basel, Switzerland) · 2024Article
- Baseline Choroidal Blood Flow Imbalance as a Predictive Factor for Macular Edema Recurrence Secondary to Branch Retinal Vein Occlusion.Diagnostics (Basel, Switzerland) · 2024Article
- Retinal and Choroidal Alterations in Diabetic Retinopathy Treatment using Subthreshold Panretinal Photocoagulation with Endpoint Management Algorithm: A Secondary Analysis of a Randomized Clinical Trial.Ophthalmology and therapy · 2023Article
- Peripapillary choroidal thickness assessed by spectral-domain optical coherence tomography in normal Japanese.Japanese journal of ophthalmology · 2021Article
- Changes in choroidal blood flow and choroidal thickness after treatment in two cases of pediatric anisohypermetropic amblyopia.American journal of ophthalmology case reports · 2017Article
- Effects of photocoagulation on ocular blood flow in patients with severe non-proliferative diabetic retinopathy.PloS one · 2017Article
- Comparison of Optic Nerve Head Blood Flow Autoregulation among Quadrants Induced by Decreased Ocular Perfusion Pressure during Vitrectomy.BioMed research international · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to investigate the relationship between choroidal blood flow and systemic and ocular variables in patients with healthy eyes.In this prospective cross-sectional study, we examined 241 eyes of 241 healthy Japanese subjects (92 males and 149 females; mean age, 37.8 ± 17.0 years). The mean blur rate, a measure of the relative blood flow of the choroid, was determined using laser speckle flowgraphy. The total cross-sectional choroidal, luminal, and stromal areas of the choroid were determined by the binarization method. We investigated the correlation between choroidal MBR and systemic and ocular variables.Choroidal mean blur rate correlated with age (r = -0.385, P < 0.001) and choroidal thickness (r = 0.264, P < 0.001). The choroidal area correlated with choroidal mean blur rate (r = 0.374, P < 0.001), age (r = -0.184, P = 0.004), axial length (r = -0.251, P < 0.001), and choroidal thickness (r = 0.468, P < 0.001). The luminal area correlated with choroidal mean blur rate (r = 0.403, P < 0.001), age (r = -0.244, P < 0.001), axial length (r = -0.218, P = 0.001), and choroidal thickness (r = 0.435, P < 0.001). On multiple stepwise regression analyses, age (β = -0.321, P < 0.001) and luminal area (β = 0.320, P < 0.001), heart rate (β = 0.136, P = 0.018), and mean ocular perfusion pressure (β = 0.126, P = 0.045) were independent factors indicating the choroidal mean blur rate. Furthermore, axial length (β = -0.352, P < 0.001), choroidal mean blur rate (β = 0.273, P < 0.001), age (β = -0.247, P < 0.001), gender (β = -0.226, P < 0.001), and mean ocular perfusion pressure (β = 0.193, P = 0.002) were independent factors indicating the luminal area.The choroidal blood flow positively correlated with the luminal area and negatively correlating with age. In addition, the luminal area was negative correlated with age. It is suggested that aging causes a reduction in choroidal blood flow and luminal area, and as a result of aging effect, decreased choroidal blood flow would correlate with decreased luminal area.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.