Evidence map›Paper›PMID 27786542›Full record

ArticleApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2016

Inhibition of Akt2 phosphorylation abolishes the calorie restriction-induced improvement in insulin-stimulated glucose uptake by rat soleus muscle.

Naveen Sharma, Edward B Arias, Gregory D Cartee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Naveen Sharmaa Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.
Edward B Ariasa Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.
Gregory D Carteea Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan–Ann Arbor · USCentral Michigan University · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Research DevelopmentP30AG013283 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, RICHARD A · 1995 to 2014
$12.3M
Aging, Calorie Restriction, Exercise and Insulin SensitivityR01AG010026 · NIA · UNIVERSITY OF WISCONSIN MADISON · PI CARTEE, GREGORY D. · 1998 to 2023
$6.8M
Skeletal Muscle Glucose Uptake: Exercise and InsulinR01DK071771 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARTEE, GREGORY D. · 2006 to 2020
$4.5M
NIA NIH HHS P30 AG013283NIA NIH HHS R01 AG010026NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK071771
6 · The paper itself

Abstract

Calorie restriction (CR; ∼60%-65% of ad libitum consumption) can enhance insulin-stimulated glucose uptake (ISGU) in predominantly slow-twitch skeletal muscles (e.g., soleus) by an incompletely understood mechanism. We used an Akt inhibitor (MK-2206) to eliminate CR's effect on insulin-stimulated Akt2 phosphorylation in isolated rat soleus muscles. We found long-term CR-enhanced ISGU was abolished by eliminating the CR effect on Akt2 phosphorylation, suggesting the CR-induced benefit on ISGU in the predominantly slow-twitch soleus relies on enhanced Akt2 phosphorylation.

Indexed as

AgingCaloric RestrictionAbsorption, PhysiologicalAnimalsCrosses, GeneticEnzyme ActivationGlucoseHeterocyclic Compounds, 3-RingHypoglycemic AgentsInsulinIn Vitro TechniquesMaleMuscle Fibers, Slow-TwitchMuscle, SkeletalPhosphorylationProtein Kinase InhibitorsAkt2 protein, ratGlucoseHeterocyclic Compounds, 3-RingHypoglycemic AgentsInsulinMK 2206Protein Kinase InhibitorsProto-Oncogene Proteins c-aktdietary restrictionglucose transportinsulin signalingmuscle à secousse lenteprotéine kinase Bprotein kinase Brestriction caloriquesignalisation de l’insulineslow-twitch muscletransport du glucose

Identifiers

PMID27786542
PMCPMC5228618
OpenAlexW2517003590

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.