Evidence map›Paper›PMID 27786513›Full record

ArticlePsychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors2016

Impact of alcohol use disorder comorbidity on defensive reactivity to errors in veterans with posttraumatic stress disorder.

Stephanie M Gorka, Annmarie MacNamara, Darrin M Aase, Eric Proescher, Justin E Greenstein, Robert Walters, Holly Passi, Joseph M Babione, David M Levy, Amy E Kennedy and 7 more

Open access · greenAbstract read
In one paragraph

Article in Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Article
  3. Error-related brain activity shapes the association between trait neuroticism and internalizing symptomatology in two tasks.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024
    Article
  4. Impact of handgun ownership and biological sex on startle reactivity to predictable and unpredictable threats.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024
    Article
  5. Article
  6. The error-related negativity (ERN) moderates the association between interpersonal stress and anxiety symptoms six months later.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020
    Article
  7. Article
  8. Error-related neural activity and alcohol use disorder: Differences from risk to remission.Progress in neuro-psychopharmacology & biological psychiatry · 2019
    Article
  9. Individual differences in combat experiences and error-related brain activity in OEF/OIF/OND veterans.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2018
    Article
  10. Article
  11. Article
  12. Article
  13. Impact of anxiety symptoms and problematic alcohol use on error-related brain activity.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Stephanie M GorkaDepartment of Psychiatry, University of Illinois at Chicago.
Annmarie MacNamaraDepartment of Psychiatry, University of Illinois at Chicago.
Darrin M AaseMental Health Service Line, Jesse Brown Veterans Administration Medical Center.
Eric ProescherDepartment of Psychiatry, University of Illinois at Chicago.
Justin E GreensteinMental Health Service Line, Jesse Brown Veterans Administration Medical Center.
Robert WaltersMental Health Service Line, Jesse Brown Veterans Administration Medical Center.
Holly PassiMental Health Service Line, Jesse Brown Veterans Administration Medical Center.
Joseph M BabioneMental Health Service Line, Jesse Brown Veterans Administration Medical Center.
David M LevyMental Health Service Line, Jesse Brown Veterans Administration Medical Center.
Amy E KennedyDepartment of Psychiatry, University of Illinois at Chicago.
Julia A DiGangiDepartment of Psychiatry, University of Illinois at Chicago.
Christine A RabinakDepartment of Pharmacy Practice and Psychiatry, Wayne State University.
Christopher SchrothDepartment of Psychiatry, University of Illinois at Chicago.
Kaveh AfsharDepartment of Psychiatry, University of Illinois at Chicago.
Jacklynn FitzgeraldDepartment of Psychiatry, University of Illinois at Chicago.
Greg HajcakDepartment of Psychology, Stony Brook University.
K Luan PhanDepartment of Psychiatry, University of Illinois at Chicago.
University of Illinois Chicago · USJesse Brown VA Medical Center · USStony Brook University · USWayne State College · US

Funding

Training in the Neuroscience of Mental HealthT32MH067631 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RASENICK, MARK M. · 2004 to 2024
$4.8M
Cannabinoid Control of Fear Extinction Neural Circuits in Post Traumatic Stress dK01MH101123 · NIMH · WAYNE STATE UNIVERSITY · PI RABINAK, CHRISTINE ANNE · 2014 to 2017
$651k
Brain-Behavior Markers of Negative Affectivity, Comorbidity in Anxiety DisordersK23MH105553 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MACNAMARA, ANNMARIE EILEEN · 2015 to 2018
$648k
NIMH NIH HHS K01 MH101123NIMH NIH HHS K23 MH105553NIMH NIH HHS T32 MH067631
6 · The paper itself

Abstract

Converging lines of evidence suggest that individuals with comorbid posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) may be characterized by heightened defensive reactivity, which serves to maintain drinking behaviors and anxiety/hyperarousal symptoms. However, it is important to note that very few studies have directly tested whether individuals with PTSD and AUD exhibit greater defensive reactivity compared with individuals with PTSD without AUD. Therefore, the aim of the current study was to test this emerging hypothesis by examining individual differences in error-related negativity (ERN), an event-related component that is larger among anxious individuals and is thought to reflect defensive reactivity to errors. Participants were 66 military veterans who completed a well-validated flanker task known to robustly elicit the ERN. Veterans were comprised of 3 groups: controls (i.e., no PTSD or AUD), PTSD-AUD (i.e., current PTSD but no AUD), and PTSD + AUD (i.e., current comorbid PTSD and AUD). Results indicated that individuals with PTSD and controls generally did not differ in ERN amplitude. However, among individuals with PTSD, those with comorbid AUD had significantly larger ERNs than those without AUD. These findings suggest that PTSD + AUD is a neurobiologically unique subtype of PTSD, and the comorbidity of AUD may enhance defensive reactivity to errors in individuals with PTSD. (PsycINFO Database Record

Indexed as

AdultAlcohol-Related DisordersBrainElectroencephalographyEvoked PotentialsFemaleHumansMaleMiddle AgedStress Disorders, Post-TraumaticVeteransYoung Adult

Identifiers

PMID27786513
PMCPMC5525136
OpenAlexW2545638192

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.