ArticleScientific reports2016
Antioxidant and Antitumor Activity of a Bioactive Polyphenolic Fraction Isolated from the Brewing Process.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Valorization of Hot Trub: Extraction and Nanoparticle Encapsulation for Antitumor Applications.Chemistry & biodiversity · 2026Article
- A critical review on the biotechnological potential of Brewers' waste: Challenges and future alternatives.Current research in microbial sciences · 2024Review
- Dietary Polyphenols against Oxidative Stress in Head and Neck Cancer: What's New, What's Next.Journal of Cancer · 2024Review
- Ethyl Gallate Isolated fromAntioxidants (Basel, Switzerland) · 2023Article
- Hyaluronic Acid within Self-Assembling Nanoparticles: Endless Possibilities for Targeted Cancer Therapy.Nanomaterials (Basel, Switzerland) · 2022Review
- The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis.Antioxidants (Basel, Switzerland) · 2021Review
- COVID-19 Risk Appears to Vary Across Different Alcoholic Beverages.Frontiers in nutrition · 2021Article
- Biological properties of almond proteins produced by aqueous and enzyme-assisted aqueous extraction processes from almond cake.Scientific reports · 2020Article
- Antioxidant Effect of Beer Polyphenols and Their Bioavailability in Dental-Derived Stem Cells (D-dSCs) and Human Intestinal Epithelial Lines (Caco-2) Cells.Stem cells international · 2020Article
- The Effect of UVB Irradiation and Oxidative Stress on the Skin Barrier-A New Method to Evaluate Sun Protection Factor Based on Electrical Impedance Spectroscopy.Sensors (Basel, Switzerland) · 2019Article
- Current Issues and Perspectives in Patients with Possible Sepsis at Emergency Departments.Antibiotics (Basel, Switzerland) · 2019Review
- Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis.International journal of obesity (2005) · 2019Article
- Strategic Tools in Regenerative and Translational Dentistry.International journal of molecular sciences · 2019Review
- Bone Metastasis Pain, from the Bench to the Bedside.International journal of molecular sciences · 2019Review
- Should we reconsider the apoptosis as a strategic player in tissue regeneration?International journal of biological sciences · 2019Review
- Probiotics Improve Urogenital Health in Women.Open access Macedonian journal of medical sciences · 2018Article
- Decellularized Hydrogels in Bone Tissue Engineering: A Topical Review.International journal of medical sciences · 2018Review
- About stem cell research in dentistry: many doubts and too many pitfalls still affect the regenerative dentistry.International journal of medical sciences · 2018Review
- Mesenchymal Stem Cells as Promoters, Enhancers, and Playmakers of the Translational Regenerative Medicine 2018.Stem cells international · 2018Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing interest in identifying natural bioactive compounds that can improve mitochondrial functionality and regulate apoptosis. The brewery industry generates wastewater that could yield a natural extract containing bioactive phenolic compounds. Polyphenols act as antioxidants and have been documented to protect the human body from degenerative diseases such as cardiovascular diseases or cancer. The main aims of our research were to determine the phenolic profile of a crude extract obtained (at pilot scale) from a brewery waste stream and to evaluate the biochemical activity of this extract on the mitochondrial function of a cancer cell line (SH-SY5Y). This work is a basic translational pilot study. The total phenolic content was determined by the Folin-Ciocalteu assay, which revealed that 2.30% of the extract consisted of phenolic compounds. The polyphenols, identified and quantified by reverse-phase-high-performance liquid chromatography and mass spectrometry (RP-HPLC/MS), were mainly flavonoids. After cell culture, the tumoral cells treated with the polyphenolic extract showed enhanced mitochondrial oxidative function, which is likely related to a decrease in oxidative stress and an increase in mitochondrial biogenesis. This type of brewery waste stream, properly treated, may be a promising source of natural antioxidants to replace the synthetic antioxidants currently used in the food industry.
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