Evidence map›Paper›PMID 27786291›Full record

ArticleScientific reports2016

Non-toxigenic environmental Vibrio cholerae O1 strain from Haiti provides evidence of pre-pandemic cholera in Hispaniola.

Taj Azarian, Afsar Ali, Judith A Johnson, Mohammad Jubair, Eleonora Cella, Massimo Ciccozzi, David J Nolan, William Farmerie, Mohammad H Rashid, Shrestha Sinha-Ray and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Genomic and epidemiological insights into a non-toxigenic Vibrio cholerae O1 Ogawa from an autochthonous case in Brazil.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Exploring Mobile Genetic Elements in Vibrio cholerae.Genome biology and evolution · 2025
    Article
  3. Article
  4. Article
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  10. Conversion of aFrontiers in microbiology · 2019
    Article
  11. Surveillance and Genomics of ToxigenicFrontiers in microbiology · 2019
    Article
  12. Review
  13. Transmission and Toxigenic Potential ofFrontiers in microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Taj AzarianEmerging Pathogens Institute, University of Florida, Gainesville, USA.
Afsar AliEmerging Pathogens Institute, University of Florida, Gainesville, USA.
Judith A JohnsonEmerging Pathogens Institute, University of Florida, Gainesville, USA.
Mohammad JubairEmerging Pathogens Institute, University of Florida, Gainesville, USA.
Eleonora CellaEmerging Pathogens Institute, University of Florida, Gainesville, USA.
Massimo CiccozziDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
David J NolanEmerging Pathogens Institute, University of Florida, Gainesville, USA.
William FarmerieInterdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida, USA.
Mohammad H RashidEmerging Pathogens Institute, University of Florida, Gainesville, USA.
Shrestha Sinha-RayEmerging Pathogens Institute, University of Florida, Gainesville, USA.
Meer T AlamEmerging Pathogens Institute, University of Florida, Gainesville, USA.
J Glenn MorrisEmerging Pathogens Institute, University of Florida, Gainesville, USA.
Marco SalemiEmerging Pathogens Institute, University of Florida, Gainesville, USA.
University of Florida · USCampus Bio Medico University Hospital · ITIstituto Superiore di Sanità · IT

Funding

Recurrence of Cholera in Haiti: Exploration of Contributing Factors and Intervention StrategiesR01AI126357 · NIAID · UNIVERSITY OF FLORIDA · PI John Glenn Morris · 2016 to 2026
$7.3M
Cholera Transmission in Gressier Region, HaitiR01AI097405 · NIAID · UNIVERSITY OF FLORIDA · PI MORRIS, JOHN GLENN · 2012 to 2015
$2.7M
NIAID NIH HHS R01 AI097405NIAID NIH HHS R01 AI126357
6 · The paper itself

Abstract

Vibrio cholerae is ubiquitous in aquatic environments, with environmental toxigenic V. cholerae O1 strains serving as a source for recurrent cholera epidemics and pandemic disease. However, a number of questions remain about long-term survival and evolution of V. cholerae strains within these aquatic environmental reservoirs. Through monitoring of the Haitian aquatic environment following the 2010 cholera epidemic, we isolated two novel non-toxigenic (ctxA/B-negative) Vibrio cholerae O1. These two isolates underwent whole-genome sequencing and were investigated through comparative genomics and Bayesian coalescent analysis. These isolates cluster in the evolutionary tree with strains responsible for clinical cholera, possessing genomic components of 6

Indexed as

Bayes TheoremCholeraCholera ToxinDNA, BacterialHaitiHumansPandemicsPhylogenySequence Analysis, DNAVibrio cholerae O1Water MicrobiologyWhole Genome SequencingCholera ToxinDNA, Bacterial

Identifiers

PMID27786291
PMCPMC5081557
OpenAlexW2541460196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.