ArticleScientific reports2016
Identification of lncRNA functions in lung cancer based on associated protein-protein interaction modules.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Predicting Protein-Protein Interactions by Convolutional Neural Network Model.Biotech (Basel (Switzerland)) · 2026Article
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- Hierarchical graph learning for protein-protein interaction.Nature communications · 2023Article
- Modular signature of long non-coding RNA association networks as a prognostic biomarker in lung cancer.BMC medical genomics · 2021Article
- LncTx: A network-based method to repurpose drugs acting on the survival-related lncRNAs in lung cancer.Computational and structural biotechnology journal · 2021Article
- Long Non-coding RNAs in Pulmonary Neuroendocrine Neoplasms.Endocrine pathology · 2020Article
- Tumour suppressive long non-coding RNA AFDN-DT inhibits gastric cancer invasion via transcriptional regulation.Journal of cellular and molecular medicine · 2020Article
- LncRNAOncoTargets and therapy · 2020Article
- Investigating the role of super-enhancer RNAs underlying embryonic stem cell differentiation.BMC genomics · 2019Article
- Risk stratification for lung adenocarcinoma on EGFR and TP53 mutation status, chemotherapy, and PD-L1 immunotherapy.Cancer medicine · 2019Article
- Article
- Expression of long non-coding RNAs (lncRNAs) has been dysregulated in non-small cell lung cancer tissues.BMC cancer · 2019Article
- Long non-coding RNA XIST predicts poor prognosis and promotes malignant phenotypes in osteosarcoma.Oncology letters · 2019Article
- LOC285629 regulates cell proliferation and motility in colorectal cancer cells.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Article
- Identification of modules of hepatic encephalopathy based on protein-protein network and gene expression data.Experimental and therapeutic medicine · 2018Article
- Long Noncoding RNA and Cancer: A New Paradigm.Cancer research · 2017Review
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Authors and funding
6 authors.
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Abstract
Long non-coding RNAs (lncRNAs) have been found to play important roles in various biological processes; however, many of their functions remain unclear. In this study, we present a novel approach to identify the lncRNA-associated protein-protein interaction (PPI) modules and ascertain their functions in human lung squamous cell carcinoma. We collected lncRNA and mRNA expression profiles of lung squamous cell carcinoma from The Cancer Genome Atlas. To identify the lncRNA-associated PPI modules, lncRNA-mRNA co-expression networks were first constructed based on the mutual ranks of expression correlations. Next, we examined whether the co-expressed mRNAs of a specific lncRNA were closely connected by PPIs. For this, a significantly connected mRNA set was considered to be the lncRNA-associated PPI module. Finally, the prospective functions of a lncRNA was inferred using Gene Ontology enrichment analysis on the associated module. We found that lncRNA-associated PPI modules were subtype-dependent and each subtype had unique molecular mechanisms. In addition, antisense lncRNAs and sense genes tended to be functionally associated. Our results might provide new directions for understanding lncRNA regulations in lung cancer. The analysis pipeline was implemented in a web tool, available at http://lncin.ym.edu.tw/.
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