ArticleNature communications2016
Molecular basis of cooperativity in pH-triggered supramolecular self-assembly.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 126 citations in OpenAlex.
- Hydrophobic Monomer Incorporation Tunes the pH Responsivity of Polycationic Brushes.ACS macro letters · 2026Article
- Electrostatics and Charge Regulation Drive Phosphate Accumulation in Cationic Dendrimers.ACS applied polymer materials · 2026Article
- Escape from cell uptake: Drug-Free cancer therapeutics regulated by hydrophobicity and negative charge.Materials today. Bio · 2026Article
- Polyanion Chemistry Engineers Ternary RNA Nanoparticle Structure/Function from the Inside-Out.ACS nano · 2026Article
- Cooperative Ligand-Mediated Transitions in Simple Macromolecules.The journal of physical chemistry. B · 2025Article
- Cascade-heterogated proton nanotransistors for multiplex pH-interval imaging.Nature communications · 2025Article
- Next-Generation Drug Delivery for Neurotherapeutics: The Promise of Stimuli-Triggered Nanocarriers.Biomedicines · 2025Review
- Mapping in situ the assembly and dynamics in aqueous supramolecular polymers.Nature communications · 2025Article
- Smart Nanoarchitectures for Precision RNA Delivery: Harnessing Endogenous and Exogenous Stimuli in Cancer Treatment.Theranostics · 2025Review
- Functionalized Polymeric Micelles for Targeted Cancer Therapy: Steps from Conceptualization to Clinical Trials.Pharmaceutics · 2024Review
- Poly(l-glutamic acid) augments the transfection performance of lipophilic polycations by overcoming tradeoffs among cytotoxicity, pDNA delivery efficiency, and serum stability.RSC applied polymers · 2024Article
- Membrane Permeability and Responsiveness Drive Performance: Linking Structural Features with the Antitumor Effectiveness of Doxorubicin-Loaded Stimuli-Triggered Polymersomes.Biomacromolecules · 2024Article
- Severely polarized extracellular acidity around tumour cells.Nature biomedical engineering · 2024Article
- Structural Determinants of Stimuli-Responsiveness in Amphiphilic Macromolecular Nano-assemblies.Progress in polymer science · 2024Article
- Elucidation of Protonation Cooperativity of a STING-Activating Polymer.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections.Nature communications · 2023Article
- Cooperativity and Frustration Effects (or Lack Thereof) in Polarizable and Non-polarizable Force Fields.Journal of chemical theory and computation · 2023Article
- Enhancing pDNA Delivery with Hydroquinine Polymers by Modulating Structure and Composition.JACS Au · 2023Article
- Review
- Cooperative transitions involving hydrophobic polyelectrolytes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Supramolecular self-assembly offers a powerful strategy to produce high-performance, stimuli-responsive nanomaterials. However, lack of molecular understanding of stimulated responses frequently hampers our ability to rationally design nanomaterials with sharp responses. Here we elucidated the molecular pathway of pH-triggered supramolecular self-assembly of a series of ultra-pH sensitive (UPS) block copolymers. Hydrophobic micellization drove divergent proton distribution in either highly protonated unimer or neutral micelle states along the majority of the titration coordinate unlike conventional small molecular or polymeric bases. This all-or-nothing two-state solution is a hallmark of positive cooperativity. Integrated modelling and experimental validation yielded a Hill coefficient of 51 in pH cooperativity for a representative UPS block copolymer, by far the largest reported in the literature. These data suggest hydrophobic micellization and resulting positive cooperativity offer a versatile strategy to convert responsive nanomaterials into binary on/off switchable systems for chemical and biological sensing, as demonstrated in an additional anion sensing model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.