ReviewLasers in surgery and medicine2017
Reflectance confocal microscopy of skin in vivo: From bench to bedside.
Review in Lasers in surgery and medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Medical hyperspectral imaging: an updated review of technology advancements and biomedical applications.Journal of biomedical optics · 2026Pooled it
- Reflectance confocal microscopy terminology glossary for melanocytic skin lesions: A systematic review.Journal of the American Academy of Dermatology · 2021Pooled it
- Reflectance confocal microscopy terminology glossary for nonmelanocytic skin lesions: A systematic review.Journal of the American Academy of Dermatology · 2019Pooled it
- Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Reflectance confocal microscopy for diagnosing keratinocyte skin cancers in adults.The Cochrane database of systematic reviews · 2018Pooled it
- In vivo imaging characterization of basal cell carcinoma and cutaneous response to high-dose ionizing radiation therapy: A prospective study of reflectance confocal microscopy, dermoscopy, and ultrasonography.Journal of the American Academy of Dermatology · 2021Trial
- Dermoscopy and the Early Melanoma Concept.International journal of dermatology · 2026Review
- Parameters characteristic of upper dermal microvasculature in patients after hematopoietic cell transplantation by noninvasive reflectance confocal videomicroscopy.Microvascular research · 2026Article
- A Prospective, Observational Study Evaluating the Diagnostic Performance of a Newly FDA-Approved Line-Field Optical Coherence Tomography (LC-OCT) in the Detection of Basal Cell Carcinoma.Lasers in surgery and medicine · 2026Observational
- Emerging In Vivo and Ex Vivo Optical Imaging Technologies in Dermatology and Dermatopathology.Dermatopathology (Basel, Switzerland) · 2026Review
- Deep-learning endomicroscope with large field-of-view and depth-of-field for real-time in vivo imaging of epithelial cancer hallmarks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Reflectance confocal microscopy in the management of lentigo maligna and lentigo maligna melanoma: a systematic review.JPRAS open · 2026Review
- Unveiling the Importance of Early Detection of Oral Mucosal Melanoma with Non-Invasive Imaging Techniques.Diagnostics (Basel, Switzerland) · 2026Review
- Live imaging of skin immunity using two-photon microscopy: a short review.Inflammation and regeneration · 2026Review
- Label-free human skin imaging with enhanced molecular contrast via time-resolved fluorescence and advanced phasor analysis.Communications biology · 2025Article
- Automated Detection of Benign and Malignant Skin Lesions from Reflectance Confocal Microscopy Images Using Deep Learning.JID innovations : skin science from molecules to population health · 2025Article
- A Microscale-Optical Interface to Examine Electric Field-Induced Cell Motility Within Whole-Eye Facsimiles.Micro · 2025Article
- Motion-tolerant 3D volumetric multimodality microscopy imaging of human skin with subcellular resolution and extended field-of-view.Communications biology · 2025Article
- Handheld multiphoton and pinhole-free reflectance confocal microscopy enables noninvasive, real-time cross-sectional imaging in skin.Scientific reports · 2024Article
- Cutting-Edge Technology Without Cutting: Treating Skin Cancer in This Era-A Case Series.Cancers · 2024Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Following more than two decades of effort, reflectance confocal microscopy (RCM) imaging of skin was granted codes for reimbursement by the US Centers for Medicare and Medicaid Services. Dermatologists in the USA have started billing and receiving reimbursement for the imaging procedure and for the reading and interpretation of images. RCM imaging combined with dermoscopic examination is guiding the triage of lesions into those that appear benign, which are being spared from biopsy, against those that appear suspicious, which are then biopsied. Thus far, a few thousand patients have been spared from biopsy of benign lesions. The journey of RCM imaging from bench to bedside is certainly a success story, but still much more work lies ahead toward wider dissemination, acceptance, and adoption. We present a brief review of RCM imaging and highlight key challenges and opportunities. The success of RCM imaging paves the way for other emerging optical technologies, as well-and our bet for the future is on multimodal approaches. Lasers Surg. Med. 49:7-19, 2017. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.