Evidence map›Paper›PMID 27785754›Full record

ArticleMolecular neurobiology2017

Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Exerts Neurotoxicity in Models of Parkinson's Disease.

Qimei Wu, Xiaoyu Yang, Lei Zhang, Yu Zhang, Linyin Feng

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 70 citations in OpenAlex.

  1. The histone deacetylase family in health and disease.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Qimei WuCAS Key Laboratory of Receptor Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, 555 Zu Chong Zhi Road, Shanghai, 201203, People's Republic of China.
Xiaoyu YangCAS Key Laboratory of Receptor Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, 555 Zu Chong Zhi Road, Shanghai, 201203, People's Republic of China.
Lei ZhangCAS Key Laboratory of Receptor Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, 555 Zu Chong Zhi Road, Shanghai, 201203, People's Republic of China.
Yu ZhangCAS Key Laboratory of Receptor Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, 555 Zu Chong Zhi Road, Shanghai, 201203, People's Republic of China.
Linyin FengCAS Key Laboratory of Receptor Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, 555 Zu Chong Zhi Road, Shanghai, 201203, People's Republic of China. lyfeng@simm.ac.cn.
Chinese Academy of Sciences · CNShanghai Institute of Materia Medica · CN

Funding

Key New Drug Creation and Manufacturing Program 2014ZX09102-001-05Scientific Innovation Project of the Chinese Academy of Sciences XDA12040304
6 · The paper itself

Abstract

Histone deacetylase 4 (HDAC4) is a class II HDAC which is highly expressed in the brain. Previous reports have shown that HDAC4 is essential for normal brain physiology and its deregulation leads to several neurodegenerative disorders. However, it remains unclear whether dysregulation of HDAC4 is specifically involved in the development of Parkinson's disease. In this study, we demonstrate that intracellular trafficking of HDAC4 is important in regulating dopaminergic cell death. While HDAC4 normally localizes to the cytoplasm, nuclear accumulation of HDAC4 was observed in dopaminergic neurons overexpressing A53T mutant α-synuclein treated with MPP

Indexed as

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinealpha-SynucleinAnimalsCell NucleusCyclic AMP Response Element-Binding ProteinDisease Models, AnimalDopaminergic NeuronsGene Expression RegulationHistone DeacetylasesHumansMaleMEF2 Transcription FactorsMice, TransgenicMutationNeurotoxinsParkinson Disease1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinealpha-SynucleinCyclic AMP Response Element-Binding ProteinHdac5 protein, mouseHistone DeacetylasesMef2a protein, mouseMEF2 Transcription FactorsNeurotoxinsProtein Kinase C-epsilonProtein Kinase InhibitorsHDAC4NeuroprotectionParkinson’s diseasePKCα-Synuclein

Identifiers

PMID27785754
OpenAlexW2544550067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.