ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2016
Melatonin restricts Pb-induced PCD by enhancing BI-1 expression in tobacco suspension cells.
Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Cloning and Functional Verification of Salt Tolerance GenePlants (Basel, Switzerland) · 2025Article
- Melatonin Mitigates Lead-Induced Oxidative Stress and Modifies Phospholipid Profile in Tobacco BY-2 Suspension Cells.International journal of molecular sciences · 2024Article
- Tannic Acid and Tea Prevents the Accumulation of Lead and Cadmium in the Lungs, Heart and Brain of Adolescent Male Wistar Rats-Possible Therapeutic Option.Animals : an open access journal from MDPI · 2022Article
- Early gene expression response of barley root tip to toxic concentrations of cadmium.Plant molecular biology · 2022Article
- Melatonin Protects Tobacco Suspension Cells against Pb-Induced Mitochondrial Dysfunction.International journal of molecular sciences · 2021Article
- Melatonin Modulates Plant Tolerance to Heavy Metal Stress: Morphological Responses to Molecular Mechanisms.International journal of molecular sciences · 2021Review
- ROS and NO Phytomelatonin-Induced Signaling Mechanisms under Metal Toxicity in Plants: A Review.Antioxidants (Basel, Switzerland) · 2021Review
- Phytomelatonin in stress management in agriculture.Heliyon · 2021Review
- Role of Melatonin in Plant Tolerance to Soil Stressors: Salinity, pH and Heavy Metals.Molecules (Basel, Switzerland) · 2020Review
- Nitric Oxide Enhances Cytotoxicity of Lead by Modulating the Generation of Reactive Oxygen Species and Is Involved in the Regulation of PbPlants (Basel, Switzerland) · 2019Article
- Osmotic Stress Induced Cell Death in Wheat Is Alleviated by Tauroursodeoxycholic Acid and Involves Endoplasmic Reticulum Stress-Related Gene Expression.Frontiers in plant science · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melatonin is a conserved substance, which was discovered in the evolutionary distant organisms like bacteria, plants, invertebrates and vertebrates. Recent studies have shown that melatonin despite its possible role in photoperiod processes, has been found to be a direct free radical scavenger and an indirect antioxidant. In this report the impact of exogenous melatonin on the Bax inhibitor-1 (BI-1) expression level in Nicotiana tabacum L. line Bright Yellow 2 (BY-2) suspension cells exposed to lead was examined. BI-1 is a well-conserved protein in plants and animals that serves as the inhibitor of mammalian proapoptotic proteins as well as plant ROS-induced cell death. Our results showed that pretreatment with 200 nm melatonin, expressing BI-1 and fortified tobacco suspension cells against damages induced by lead. The obtained results revealed, that melatonin significantly increases BY-2 cells proliferation and protects BY-2 cells against death. Moreover, the conducted analyses showed for the first time that the protective effect of melatonin may be connected not only with its antioxidant properties but also with its direct impact on elevating BI-1 expression and lead-induced programmed cell death (PCD) restriction.
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